Alpha-Linolenic Acid and Cardiovascular Events: A Narrative Review. [PDF]
Int J Mol Sci, 2023 Cardiovascular diseases (CVDs) represent the leading cause of global mortality with 1,7 million deaths a year. One of the alternative systems to drug therapy to minimize the risk of CVDs is represented by alpha-linolenic acid (ALA), an essential fatty acid of the Omega-3 series, known for its cholesterol-lowering effect. The main purpose of this review
Bertoni C +5 more
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Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway [PDF]
Nutrition & Metabolism, 2022 Background Altered lipid profiles are frequently present in cancer, and it is necessary to elucidate the role of changed lipid profiles in hepatocellular carcinoma (HCC). We conducted this study to investigate the changed lipid profile in HCC tissues and
Shu Feng +5 more
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Alpha-linolenic acid-mediated epigenetic reprogramming of cervical cancer cell lines [PDF]
EpigeneticsCervical cancer, the fourth most common cancer globally and the second most prevalent cancer among women in India, is primarily caused by Human Papilloma Virus (HPV).
Amrita Ulhe +3 more
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Dietary Alpha-Linolenic Acid Supports High Retinal DHA Levels. [PDF]
Nutrients, 2022 Sinclair AJ, Guo XF, Abedin L.
europepmc +4 more sources
Identification of the alpha linolenic acid metabolism-related signature associated with prognosis and the immune microenvironment in nasopharyngeal carcinoma [PDF]
Frontiers in Endocrinology, 2022 BackgroundTumor metabolism is important for cancer progression. Nevertheless, the role of the metabolism pathway and related molecules in nasopharyngeal carcinoma (NPC) is limited.MethodsOpen-accessed data was downloaded from The Cancer Genome Atlas ...
Zhijie Fang +3 more
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Alpha-Linolenic Acid: Is It Essential to Cardiovascular Health? [PDF]
Current Atherosclerosis Reports, 2010 There is a large body of scientific evidence that has been confirmed in randomized controlled trials indicating a cardioprotective effect for omega-3 fatty acids from fish.
Johanna M. Geleijnse +2 more
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Circulation, 2005 Although the fish-derived, long-chain omega-3 fatty acids (n-3 FA) may be considered “gifts from the sea” for cardiovascular health, the role of the land (or plant) -based n-3 FA α-linolenic acid (ALA) has been less clear. ALA is the 18-carbon, 3-double bond (C18:3n-3) precursor to eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA ...
William S. Harris
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Alleviation of Fatty Liver by .ALPHA.-Linolenic Acid
Journal of Nutritional Science and Vitaminology, 2004 We compared the efficacy of alpha-linolenic acid (alpha-LNA, n-3) and linoleic acid (LA, n-6) on orotic acid (OA)-induced fatty liver in Sprague-Dawley rats. Rats were fed semi-synthetic diets containing either LA or alpha-LNA with or without 1% OA for 2 wk. OA supplementation lowered serum lipids in LA+OA groups.
Yohanes, Buang +5 more
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The Significance of Alpha-Linolenic Acid for Humans.
Journal of Oleo Science, 2001 The omega 3 polyunsaturated fatty acids have had a major impact on thinking in medicine in the last twenty-five years. The parent fatty acid in the omega 3 fatty acid family is alpha-linolenic acid (ALA) which is an essential fatty acid found in high concentrations in certain plant oils, such as flaxseed oil, walnut oil and canola oil.
Andrew J. SINCLAIR, Duo LI
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Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. [PDF]
PLoS ONE, 2013 Alpha linolenic acid (ALA) is the major omega-3 fatty acid in the diet. Evidence on health effects of ALA is not conclusive, but some observational studies found an increased risk of prostate cancer with higher intake of ALA.
Ingeborg A Brouwer +8 more
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