Results 51 to 60 of about 6,542 (163)

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

STUDIES ON A NOVEL RECOMBINANT LIPASE A FROM BACILLUS SUBTILIS FS2

ASEAN Journal on Science and Technology for Development, 2017
A strain of Bacillus subtilis FS2 isolated from a traditional fish source in Vietnam has been shown to produce an enzyme possessing both a gelatinase and a lipase A (LipA) activity when tested on agar plates containing 0.1% tributyrin and 0.3% gelatine ...
Phung Thu Nguyet, Nguyen Hong Thanh, Truong Nam Hai, Jan-Christer Janson   +3 more
doaj   +1 more source

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

International Journal of Cancer, EarlyView.
ABSTRACT Penile cancer is a severe disease, and a large proportion is related to high‐risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population‐based data on the prevalence of p16 in penile cancer is scarce.
Marianne Gardar Stærk, Birgitte Grønkær Toft, Christina Stilling, Johanna Elversang, Sanne Kjær‐Frifeldt, Sonja Höhle Hjulskov, Sanja Stifter‐Vretenar, Marie Aarslev Schou, Mikael Aagaard, Peter Meidahl Petersen, Jakob Kristian Jakobsen, Christian Munk, Susanne Krüger Kjær   +12 more
wiley   +1 more source

Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea. [PDF]

PLoS ONE, 2014
Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the metabolic capacity of difficult-to-study organisms and their abiotic environmental interactions?
Kirill Borziak, Mareike G Posner, Abhishek Upadhyay, Michael J Danson, Stefan Bagby, Steve Dorus   +5 more
doaj   +1 more source

Target‐site mutations and phenotypic failure in Myzus persicae against pyrethroids and carbamates in central Europe

Pest Management Science, EarlyView.
Molecular screening of 140 field‐collected Myzus persicae aphids revealed target‐site mutations L1014F, M918L, M918T, and L932F in the sodium channel and S431F in Ace2. The M918L mutation was the primary driver of high pyrethroid (cypermethrin) resistance, while S431F served as a definitive marker for carbamate (pirimicarb) resistance.
Jitka Stara, Jan Hubert, Pavla Pabiskova, Frantisek Kocourek   +3 more
wiley   +1 more source

Interpreting coronary artery disease GWAS results: A functional genomics approach assessing biological significance.

PLoS ONE, 2022
Genome-wide association studies (GWAS) have implicated 58 loci in coronary artery disease (CAD). However, the biological basis for these associations, the relevant genes, and causative variants often remain uncertain. Since the vast majority of GWAS loci
Katherine Hartmann, Michał Seweryn, Wolfgang Sadee   +2 more
doaj   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, EarlyView.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Mutations identified in a cohort of Mexican patients with lysosomal acid lipase deficiency

Annals of Hepatology, 2019
Introduction and Objectives: Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive disease caused by mutations in the LIPA gene, located on the long arm of chromosome 10 (10q23.31).
Alejandra Consuelo-Sánchez, Rodrigo Vázquez-Frias, Alejandra Reyes-De La Rosa, Carlos P. Acosta-Rodríguez-Bueno, María P. Ortal-Vite, Jorge J. Cebolla   +5 more
doaj   +1 more source

Overproduction of α-Lipoic Acid by Gene Manipulated Escherichia coli. [PDF]

PLoS ONE, 2017
Alpha-lipoic acid (LA) is an important enzyme cofactor widely used by organisms and is also a natural antioxidant for the treatment of pathologies driven by low levels of endogenous antioxidants.
Yirong Sun, Wenbin Zhang, Jincheng Ma, Hongshen Pang, Haihong Wang   +4 more
doaj   +1 more source

The association between 24‐hr movement patterns and self‐harm incidence in adolescence

Journal of Child Psychology and Psychiatry, EarlyView.
Background Self‐harm is a pressing public health issue, particularly among adolescents. Physical activity is associated with reduced self‐harm among youths, but evidence is limited. Most studies rely on self‐reported measures and are primarily focused on moderate‐to‐vigorous physical activity (MVPA), often overlooking the role of light‐intensity ...
Siyi Huang, Jiameng Cui, Qida He, Shahmir H. Ali, Qi Wang, G. Neil Thomas, Linyan Li   +6 more
wiley   +1 more source