Results 61 to 70 of about 6,542 (163)

Macrophage lipid efflux regulates the tumour microenvironment in early‐stage lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
1. Macrophages undergo metabolic rewiring even during early tumourigenesis. 2. Main alterations of macrophages are conserved between human and mice in early‐stage lung adenocarcinoma. 3. Tumour‐associated macrophages are characterised by enhanced lipid efflux 4.
Yujie Zheng, Yuan Wang, Yalin Wang, Yue Shi, Hui Kong, Shaohua Lu, Yong Zhang, Jie Hu, Jian Zhou, Xiangdong Wang, Meng Xiang, Qiong Liu, Hongyi Xin, Charles A. Powell, Fred R. Hirsch, Chunxue Bai, Yuanlin Song, Jun Yin, Dawei Yang   +18 more
wiley   +1 more source

Large-scale gene-centric analysis identifies novel variants for coronary artery disease.

PLoS Genetics, 2011
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including ...
IBC 50K CAD Consortium
doaj   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, Volume 35, Issue 5, Page 576-593, October 2026.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Comparison of rapid tests for detection of rifampicin-resistant Mycobacterium tuberculosis in Kampala, Uganda

BMC Infectious Diseases, 2009
Background Drug resistant tuberculosis (TB) is a growing concern worldwide. Rapid detection of resistance expedites appropriate intervention to control the disease.
McNerney Ruth, Jones-López Edward C, Kayes Susan, Eisenach Kathleen D, Okwera Alphonse, Mumbowa Francis, Traore Hamidou, Asiimwe Benon B, Ogwang Sam, Worodria William, Ayakaka Irene, Mugerwa Roy D, Smith Peter G, Ellner Jerrold, Joloba Moses L   +14 more
doaj   +1 more source

ASXL1 in proinflammatory macrophages attenuates inflammatory activation and macrophage‐mediated renal tubular epithelial cell damage in acute kidney injury

Physiological Reports, Volume 14, Issue 19, October 2026.
ASXL1 in inflammatory macrophages attenuates renal tubular cell damage through coordinated histone modification of H3K27me3 and H3K4me3 in acute kidney injury. Abstract Macrophages are major contributors to inflammatory responses in acute kidney injury (AKI) and rapidly alter their gene expression through epigenetic regulation.
Yoshiyasu Ogura, Takehito Sugasawa, Masaomi Nangaku, Imari Mimura   +3 more
wiley   +1 more source

Characterization of Mycobacterium chelonae-Like Strains by Comparative Genomics

Frontiers in Microbiology, 2017
Isolates of the Mycobacterium chelonae-M. abscessus complex are subdivided into four clusters (CHI to CHIV) in the INNO-LiPA® Mycobacterium spp DNA strip assay. A considerable phenotypic variability was observed among isolates of the CHII cluster.
Christiane L. Nogueira, Luiz G. P. de Almeida, Maria C. Menendez, Maria J. Garcia, Luciano A. Digiampietri, Erica Chimara, Margo Cnockaert, Juan C. Palomino, Françoise Portaels, Anandi Martin, Peter Vandamme, Sylvia C. Leão   +11 more
doaj   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, Volume 4, Issue 3, September 2026.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Identification and analysis of genomic islands in Burkholderia cenocepacia AU 1054 with emphasis on pathogenicity islands

BMC Microbiology, 2017
Background Genomic islands (GIs) are genomic regions that reveal evidence of horizontal DNA transfer. They can code for many functions and may augment a bacterium’s adaptation to its host or environment.
Feng-Biao Guo, Lifeng Xiong, Kai-Yue Zhang, Chuan Dong, Fa-Zhan Zhang, Patrick C.Y. Woo   +5 more
doaj   +1 more source

HPV‐Associated Adenosquamous Carcinoma of the Oropharynx With a PARD3B::ERBB4 Fusion

Genes, Chromosomes and Cancer, Volume 65, Issue 9, September 2026.
ABSTRACT Head and neck carcinomas can be diagnostically challenging because of their diverse histologic subtypes. We report a case of a 55‐year‐old male presenting with right‐sided cervical adenopathy, in whom imaging revealed a cystic lesion that was subsequently confirmed to be metastatic from a lesion at the base of the tongue.
Seddig Momenkhan, Jacques Blanc, Pierre Philouze, Jonathan Lopez, Francoise Descotes, Eudeline Alix, Camille Leonce, Ziyad Alsugair, Nazim Benzerdjeb   +8 more
wiley   +1 more source

Choleteryl ester storage disease: A rare cause of adrenal calcifications in children

Apollo Medicine, 2020
Cholesteryl ester storage disease (CESD) in children is a rare anatomo-clinical entity, characterized by a secondary lysosomal accumulation and an autosomal recessive mutation in the LIPA gene, which results from a lysosomal acid lipase (LAL) deficiency.
Fatiha Benmiloud, Maria Rkain, A El Aouali, A Babakhouya, Noufissa Benajiba   +4 more
doaj   +1 more source