Results 161 to 170 of about 158,005 (297)

Lipid-lowering drug therapies: the evidence [PDF]

Proceedings of the Nutrition Society, 2000
openaire   +2 more sources

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

CT-Guided Lipid-Lowering Therapy Leading to Functional Resolution of Ischemia. [PDF]

JACC Case Rep
Kołtowski Ł, Juszczyk J, Tajima A, Collet C, Antoniak R, Krajewska N, Borodzicz-Jażdżyk S, Kochman J, Opolski G, Grabowski M.   +9 more
europepmc   +1 more source

Benefits of Lipid-Lowering Therapy [PDF]

The Journal of the American Board of Family Medicine, 1998
J. H. Stein, P. McBride
openaire   +1 more source

Residual cardiovascular risk in patients who received lipid-lowering treatment in a real-life setting: retrospective study

, 2016
Valentina Perrone, Diego Sangiorgi, Stefano Buda, Luca Degli Esposti, CliCon S.r.l., Health, Economics & Outcomes Research, Ravenna, Italy Introduction: The objective of this study was twofold: 1) to assess the residual cardiovascular (CV) risk among
Perrone V, Sangiorgi D, Buda S, Degli Esposti L   +3 more
core  

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Lipid-lowering therapy for primary prevention of cardiovascular disease in adults aged 75 years and older: a narrative review. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Stephan D, Zamperini C, Cordeanu EM.
europepmc   +1 more source

An evaluation of lipid-lowering therapy in CABG patients at UMass Memorial Hospital

, 2001
The purpose of this MQP was to evaluate preventative lipid-lowering therapy after coronary artery bypass grafting (CABG) at UMass Hospital. Coronary artery bypass grafting is a palliative operation for patients when their atherosclerotic process has ...
Smith, Lakee T.
core  

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source