Results 41 to 50 of about 3,233,582 (249)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Retrospective assessment of the effectiveness of lipid-lowering therapy in patients with hypertriglyceridemia in real-world clinical practice

КардиоСоматика
BACKGROUND: Elevated triglyceride levels—hypertriglyceridemia, representing an imbalance of lipid parameters—play a key role in contemporary lipid metabolism research and are associated with an increased risk of atherosclerotic cardiovascular disease. An
Alexandr V. Shomin, Elena K. Serezhina, Andrey G. Obrezan   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lipid lowering therapy.

, 2013
Lipid lowering therapy.
Zhi Jian Wang (400794), Xiao Li Liu (400795), Yu Jie Zhou (400790), Fei Gao (29262), Shi Wei Yang (137758), Da Yi Hu (400791), Ying Xin Zhao (400792), Yu Yang Liu (400793)   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Innovative lipid-lowering therapy: experience of inclisiran use in the Republic of Belarus

Российский кардиологический журнал, 2023
The article reflects modern aspects of lipid-lowering therapy, based on the as­sessment of cardiovascular risk, and the possibilities of triple therapy, including statins, ezetimibe, and inclisiran.We present our own data on the use of the drug ...
E. A. Medvedeva, E. A. Grigorenko, N. P. Mitkovskaya   +2 more
doaj   +1 more source

Use of lipid-lowering therapy.

, 2015
aNon-statin LLT: ezetimibe, fibrates, nicotinic acid, anion exchange resins.LLT, lipid-lowering therapy; SCORE, Systematic Coronary Risk Evaluation.Use of lipid-lowering therapy.
José R. Banegas (318601), Joep Perk (693176), Julian P. Halcox (693173), Claudio Borghi (654027), Esther Lopez-Garcia (5068805), Ogün Sazova (693177), Fernando Rodriguez-Artalejo (4657693), Guy De Backer (693174), Jean Dallongeville (224373), Eliseo Guallar (27363), Jesús Medina (693175), Carine Roy (84997), Stephen Sweet (693178), Florence Tubach (77841)   +13 more
core   +1 more source

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials [PDF]

, 2012
Background - It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins.
Jacquet Hervet, Michel, Pieter Kamphuisen, Wikstrand John, Bhala, Neeraj, Haluska, B. A., Sara Biere-Rafi (135090), Kostner, K., Emberson, J, Hegney, D., Pieter Kamphuisen (135078), Bolte, J., McMurray, J.J.V., Delhaas, T., Holliday, J., Wikstrand, J, Glasziou, P. P., Hall, A. S., Samani, N. J., Emberson, J., Carrington, M. J., Blankenberg, S., Reino Maceiras, Maria Victoria, Ling, H. L., Álvarez Álvarez, Belén, Alvarez Castro, Ezequiel, Michele Robertson (135100), Sara Biere-Rafi, Agra Bermejo, Rosa Maria, McMurray, John, Kazem Rahimi (135073), Kamphuisen, P., Frueh, M., Kamphuisen, Pieter, McMurray, J., Schute, F., McMurray John, Biere-Rafi, Sara, Reha-Sleep-Registry, Paradela Dobarro, Beatriz, García Acuña, José María, Janousek, J., Robertson, Michele, Wikstrand, John, Abuassi, Emad, Robertson, M., Kamphuisen, P, Kamke, W., Robertson Michele, Michele Robertson, Zeller, T., Biere-Rafi Sara, Stewart, S., McMurray, J, Peña Gil, Carlos, Rodiño Janeiro, Bruno K, Musameh, M. D., John McMurray, Wang, W. Y. S., Emberson Jonathan, S. Caravita, A. Faini, Neeraj Bhala (135075), John Wikstrand, John McMurray (135109), Keech, A. C., Vera Krane (135094), Jonathan Emberson, Van Geldorp, I., Jonathan Emberson (135084), Rahimi, Kazem, Tonkin, A. M., Elders, J., Rahimi, K, Schroeder, K., S. Salerno, Krane Vera, Krane, V, Vera Krane, Sullivan, D. R., Wikstrand, John,, Bhala, N., Prinzen, F. W., Nelson, C. P., E. Lisi, Krane, V., Biere-Rafi, S., Alt, B., Neeraj Bhala, Skobel, E., Grigorian Shamagian, Lilian, Ball, S. G., G. Parati, Biere-Rafi, S, Kazem Rahimi, ?, ?, Balmforth, A. J., Tomaszewski, M., M. Valentini, John Wikstrand (135105), White, H. D., Carrington, M., Schwaab, B., Rosenthal, E., Raposeiras Roubín, Sergio, Gestal Romani, Santiago, Bhala Neeraj, Cabanas Grandio, Maria Pilar, Emberson, Jonathan, Woehrle, H., Kamphuisen Pieter, Espinoza, D., Tomaske, M., Bhala, N, Hague, W., Rahimi Kazem, G. Bilo, Krane, Vera, P. Agostoni, Rahimi, K., Haluska, B., Krupickova, S., González Juanatey, José Ramón, González Cambeiro, María Cristina, Marwick, T. H., Wikstrand, J., Hiippala, A., Pereira Lopez, Eva Maria, Aguiar Souto, Pablo, Purucker, H. C., Boenner, G., Krüger, S., M. Revera, Simes, R. J., C. Lombardi, Robertson, M   +134 more
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy [PDF]

, 2023
BACKGROUND The frequency, characteristics and outcomes of patients treated with high-intensity lipid-lowering therapy and showing concomitant atheroma volume reduction, lipid content reduction, and increase in fibrous cap thickness (i.e., "triple ...
van Geuns, Robert-Jan, Shibutani, Hiroki, Otsuka, Tatsuhiko, Kakizaki, Ryota, Spirk, David, Koskinas, Konstantinos C., Engstrøm, Thomas, Lang, Irene, Losdat, Sylvain, Hofbauer, Thomas M, Heg, Dik, Iglesias, Juan, Siontis, Georgios Cm, Lorenz Räber, Biccirè, Flavio G, Häner, Jonas, Iglesias, Juan F., Jonas Häner, Flavio G. Biccirè, Tatsuhiko Otsuka, Sylvain Losdat, David Spirk, Konstantinos C. Koskinas, Bär, Sarah, Stephan Windecker, Lønborg, Jacob, Robert-Jan van Geuns, Jacob Lønborg, Daemen, Joost, Thomas M. Hofbauer, Juan F. Iglesias, George C.M. Siontis, Biccirè, Flavio G., Thomas Engstrøm, Ryota Kakizaki, Sarah Bär, Christoph Kaiser, Hofbauer, Thomas M., Siontis, George C.M., Joost Daemen, Kaiser, Christoph, Stefan Stortecky, van Geuns, Robert Jan, Windecker, Stephan, Hiroki Shibutani, Stortecky, Stefan, Yasushi Ueki, Irene Lang, Dik Heg, Koskinas, Konstantinos C, Räber, Lorenz, Ueki, Yasushi   +51 more
core   +3 more sources