Results 41 to 50 of about 158,005 (297)

Lipid Lowering Therapy in the Elderly: Is there a Benefit?

Current Pharmaceutical Design, 2006
The rising number of elderly people has a major impact on healthcare systems. Advancing age is a risk factor for the development of cardiovascular disease (CVD), which represents a major global healthcare problem. The clinical efficacy and safety of lipid lowering treatment (especially statins) is well established following a series of large-scale ...
Kalantzi, K. J., Milionis, H. J., Mikhailidis, D. P., Goudevenos, J. A.   +3 more
openaire   +3 more sources

Personalize and Optimize Lipid-Lowering Therapies

Journal of the American College of Cardiology, 2016
IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) demonstrated that intensive lipid-lowering therapy with ezetimibe/simvastatin reduced first and subsequent cardiovascular events compared with placebo/simvastatin.
Oliver, Weingärtner, Dieter, Lütjohann, Albrecht, Elsässer   +2 more
openaire   +2 more sources

Optimal lipid modification: the rationale for combination therapy [PDF]

, 2005
James M Backes1, Cheryl A Gibson2, Patricia A Howard31Department of Pharmacy Practice, Lipid, Atherosclerosis, Metabolic and LDL Apheresis Center, University of Kansas Medical Center, Kansas City, KS, USA; 2Department of Internal Medicine, University of ...
James M Backes, Backes, James M., Howard, Patricia A., Cheryl A Gibson, Gibson, Cheryl A., Patricia A Howard   +5 more
core   +1 more source

Association of Lowering Low‐Density Lipoprotein Cholesterol With Contemporary Lipid‐Lowering Therapies and Risk of Diabetes Mellitus: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The relationship between lowering LDL (low‐density lipoprotein) cholesterol with contemporary lipid‐lowering therapies and incident diabetes mellitus (DM) remains uncertain.
Safi U. Khan, Hammad Rahman, Victor Okunrintemi, Haris Riaz, Muhammad Shahzeb Khan, Sudhakar Sattur, Edo Kaluski, A. Michael Lincoff, Seth S. Martin, Michael J. Blaha   +9 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials [PDF]

, 2012
Background - It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins.
Jacquet Hervet, Michel, Pieter Kamphuisen, Wikstrand John, Bhala, Neeraj, Haluska, B. A., Sara Biere-Rafi (135090), Kostner, K., Emberson, J, Hegney, D., Pieter Kamphuisen (135078), Bolte, J., McMurray, J.J.V., Delhaas, T., Holliday, J., Wikstrand, J, Glasziou, P. P., Hall, A. S., Samani, N. J., Emberson, J., Carrington, M. J., Blankenberg, S., Reino Maceiras, Maria Victoria, Ling, H. L., Álvarez Álvarez, Belén, Alvarez Castro, Ezequiel, Michele Robertson (135100), Sara Biere-Rafi, Agra Bermejo, Rosa Maria, McMurray, John, Kazem Rahimi (135073), Kamphuisen, P., Frueh, M., Kamphuisen, Pieter, McMurray, J., Schute, F., McMurray John, Biere-Rafi, Sara, Reha-Sleep-Registry, Paradela Dobarro, Beatriz, García Acuña, José María, Janousek, J., Robertson, Michele, Wikstrand, John, Abuassi, Emad, Robertson, M., Kamphuisen, P, Kamke, W., Robertson Michele, Michele Robertson, Zeller, T., Biere-Rafi Sara, Stewart, S., McMurray, J, Peña Gil, Carlos, Rodiño Janeiro, Bruno K, Musameh, M. D., John McMurray, Wang, W. Y. S., Emberson Jonathan, S. Caravita, A. Faini, Neeraj Bhala (135075), John Wikstrand, John McMurray (135109), Keech, A. C., Vera Krane (135094), Jonathan Emberson, Van Geldorp, I., Jonathan Emberson (135084), Rahimi, Kazem, Tonkin, A. M., Elders, J., Rahimi, K, Schroeder, K., S. Salerno, Krane Vera, Krane, V, Vera Krane, Sullivan, D. R., Wikstrand, John,, Bhala, N., Prinzen, F. W., Nelson, C. P., E. Lisi, Krane, V., Biere-Rafi, S., Alt, B., Neeraj Bhala, Skobel, E., Grigorian Shamagian, Lilian, Ball, S. G., G. Parati, Biere-Rafi, S, Kazem Rahimi, ?, ?, Balmforth, A. J., Tomaszewski, M., M. Valentini, John Wikstrand (135105), White, H. D., Carrington, M., Schwaab, B., Rosenthal, E., Raposeiras Roubín, Sergio, Gestal Romani, Santiago, Bhala Neeraj, Cabanas Grandio, Maria Pilar, Emberson, Jonathan, Woehrle, H., Kamphuisen Pieter, Espinoza, D., Tomaske, M., Bhala, N, Hague, W., Rahimi Kazem, G. Bilo, Krane, Vera, P. Agostoni, Rahimi, K., Haluska, B., Krupickova, S., González Juanatey, José Ramón, González Cambeiro, María Cristina, Marwick, T. H., Wikstrand, J., Hiippala, A., Pereira Lopez, Eva Maria, Aguiar Souto, Pablo, Purucker, H. C., Boenner, G., Krüger, S., M. Revera, Simes, R. J., C. Lombardi, Robertson, M   +134 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Retrospective assessment of the effectiveness of lipid-lowering therapy in patients with hypertriglyceridemia in real-world clinical practice

КардиоСоматика
BACKGROUND: Elevated triglyceride levels—hypertriglyceridemia, representing an imbalance of lipid parameters—play a key role in contemporary lipid metabolism research and are associated with an increased risk of atherosclerotic cardiovascular disease. An
Alexandr V. Shomin, Elena K. Serezhina, Andrey G. Obrezan   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source