Results 61 to 70 of about 1,789,531 (316)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Abundance of Colistin-Resistant, OXA-23- and ArmA-Producing Acinetobacter baumannii Belonging to International Clone 2 in Greece

Frontiers in Microbiology, 2020
Carbapenem resistant Acinetobacter baumannii (CRAB) represents one of the most challenging pathogens in clinical settings. Colistin is routinely used for treatment of infections by this pathogen, but increasing colistin resistance has been reported.
Mattia Palmieri, Marco Maria D’Andrea, Marco Maria D’Andrea, Andreu Coello Pelegrin, Nadine Perrot, Caroline Mirande, Bernadette Blanc, Nicholas Legakis, Herman Goossens, Gian Maria Rossolini, Gian Maria Rossolini, Alex van Belkum   +11 more
doaj   +1 more source

Ecological optimization of biomass and lipid production by microalgae [PDF]

, 2012
Microalgae have higher growth rates and higher lipid content than terrestrial plants and the yield per unit area is even higher by several orders of magnitude.
Stockenreiter, Maria
core  

Solution structure of a repeated unit of the ABA-1 nematode polyprotein allergen of ascaris reveals a novel fold and two discrete lipid-binding sites [PDF]

, 2011
Parasitic nematode worms cause serious health problems in humans and other animals. They can induce allergic-type immune responses, which can be harmful but may at the same time protect against the infections. Allergens are proteins that trigger allergic
Ball, G., Smith, B.O., Cooper, Alan, Bromek Krystyna, Malcolm W Kennedy, Smith Brian O., Meenan, N.A.G., Bromek, K., Uhrín, D., Uhrin, Dusan, Cooper Alan, Brian O. Smith, Meenan, N., Krystyna Bromek, Bromek, Krystyna, Kennedy, M.W., Ball Graeme, Brian O Smith, Meenan, Nicola A. G., Alan Cooper, Uhrín Dušan, Cooper, A., Kennedy, M., Nicola A. G. Meenan, Malcolm W. Kennedy, Graeme Ball, Nicola A G Meenan, Kennedy, Malcolm W., Meenan Nicola A. G., Dušan Uhrín, Ball, Graeme, Kennedy Malcolm W., Smith, B., Smith, Brian O.   +33 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Molecular Interaction of a New Antibacterial Polymer with a Supported Lipid Bilayer Measured by an in situ Label-Free Optical Technique

, 2013
The interaction of the antibacterial polymer–branched poly(ethylene imine) substituted with quaternary ammonium groups, PEO and alkyl chains, PEI25QI5J5A815–with a solid supported lipid bilayer was investigated using surface sensitive optical waveguide ...
Éva Kiss, Horváth, Róbert, Kobzi, Balázs, Robert Horvath, Helmut Keul, Balázs Kobzi, Martin Moeller, Keul, Helmut, Kiss, Éva, Möller, Martin   +9 more
core   +1 more source

Evaluation of seven common lipid associated loci in a large Indian sib pair study. [PDF]

, 2012
BACKGROUND: Genome wide association studies (GWAS), mostly in Europeans have identified several common variants as associated with key lipid traits. Replication of these genetic effects in South Asian populations is important since it would suggest wider
K Srinath Reddy, Nicholas J Timpson, Rafiq, Sajjad, Madana, Sandeep N, Reddy, K Srinath, Giriraj R Chandak, Frank Dudbridge, Bowen, Liza, Yoav Ben-Shlomo, Sanjay Kinra, Venkata, Kranthi Kumar M, Shah Ebrahim, Chandak, Giriraj R, Charles J Spurgeon, Ebrahim, Shah, Sajjad Rafiq, Sandeep N Madana, Kranthi Kumar M Venkata, Vinay, DG, DG Vinay, Gupta, Vipin, Dudbridge, Frank, Timpson, Nicholas J, Smith, George Davey, Liza Bowen, Guru, Vinay D, Smitha Parameshwaran, Parameshwaran, Smitha, Indian Migration Study Group, Venkata, Kranthi Kumar, null null, Vipin Gupta, Prabhakaran, Dorairaj, George Davey Smith, Spurgeon, Charles J, Kinra, Sanjay, Ben-Shlomo, Yoav, Dorairaj Prabhakaran   +37 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source