Results 121 to 130 of about 4,174,905 (243)

Theaflavins Attenuate Hepatic Lipid Accumulation through Activating Ampk in Human Hepg2 Cells

, 2008
Black tea is one of the world's most popular beverages, and its health- promoting effects have been intensively investigated. The antiobesity and hypolipidemic effects of black tea have attracted increasing interest, but the mechanisms underlying these ...
Lin, Chih-Li; Huang, Hsiu-Chen; Lin, Jen-Kun, 林志立;林仁混   +1 more
core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Aaptamine Inhibits Lipid Accumulation and Pparg and Slc2a4 Expression While Maintaining the Methylation of the Pparg Promoter During 3T3-L1 Adipocyte Differentiation [PDF]

Eko Fuji Ariyanto,1 Ibnu Wijaya,2 Zaky Alif Pradian,2 Agung Putri Mayasari Bhaskara,2 Mohammad Parezal Lastialno,3 Putri Halleyana Adrikni Rahman,1 Muhammad Hasan Bashari,1 Nandina Oktavia,1 Muhammad Iman Pratama Putra,4 Yuni Susanti Pratiwi,1 Henhen ...
Pradian ZA, Rahman PHA, Dhianawaty D, Ariyanto EF, Heryaman H, Oktavia N, Bhaskara APM, Putra MIP, Lastialno MP, Bashari MH, Wijaya I, Pratiwi YS   +11 more
core  

Urine Glucose Excretion Attenuates the Association Between Lipid Accumulation Product and Serum Uric Acid in Subjects with Prediabetes

Diabetes, Metabolic Syndrome and Obesity, 2020
Juan Chen,1 Yu Liu,2 Haijian Guo,3 Bei Wang,4 Zilin Sun,2 Jiangyi Yu1 1Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China ...
Chen J, Liu Y, Guo H, Wang B, Sun Z, Yu J   +5 more
doaj  

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Lipid accumulation product is associated with metabolic syndrome in women with polycystic ovary syndrome

, 2016
OBJECTIVE: There is a need for a simple and accurate method for the assessment of cardiovascular risk in polycystic ovary syndrome (PCOS). Lipid accumulation product (LAP) is based on the assessment of waist circumference and serum triglycerides that ...
Stanojlović, Olivera, Milić, Nataša, Macut, Djuro, Božić Antić, Ivana, Vojnović Milutinović, Danijela, Petakov, Milan, Panidis, Dimitrios, Bjekić-Macut, Jelica, Kastratović-Kotlica, Biljana, Tziomalos, Konstantinos   +9 more
core   +1 more source

Arachidonic Acid Production by Mortierella alpina on Brewery Spent Malt Enriched with Vegetable Oils Using Solid-State Fermentation

Fermentation
Arachidonic acid (AA) is a high-value long-chain polyunsaturated fatty acid commonly produced by submerged fermentation of oleaginous fungi. Solid-state fermentation (SSF) using low-cost agro-industrial by-products represents a promising alternative ...
Silvia Stredanská, Janka Kubincová, Mária Kopuncová, Eugen Kiss, Stanislav Baxa, Miroslav Stredanský   +5 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source