Results 41 to 50 of about 199,281 (229)

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Method of fabricating lipid bilayer membranes on solid supports [PDF]

, 2012
The present invention provides a method of producing a planar lipid bilayer on a solid support. With this method, a solution of lipid vesicles is first deposited on the solid support.
Cheong, Kwang Ho, Cho, Nam-Joon, Frank, Curtis W., Glenn, Jeffrey S.   +3 more
core   +1 more source

Functional role of water in membranes updated: A tribute to Träuble [PDF]

, 2015
The classical view of a cell membrane is as a hydrophobic slab in which only nonpolar solutes can dissolve and permeate. However, water-soluble non-electrolytes such as glycerol, erythritol, urea and others can permeate lipid membranes in the liquid ...
Bouchet, Ana María, Disalvo, Edgardo Anibal, Frías, María de los Ángeles, Hollmann, Axel, Martini, María Florencia, Pinto, Oscar Alejandro   +5 more
core   +1 more source

Microrheology of Freestanding Lipid Bilayers [PDF]

Biophysical Journal, 2010
The macroscopic material properties of cellular membranes, determined by the composition and interactions of their constituent lipids, are important factors in the structure and function of all living cells. Fluidity is a key material property of membranes, yet the underlying lipid bilayer viscosity and other rheological parameters remain poorly ...
Miranda J. Bradley, Christopher W. Harland, Raghuveer Parthasarathy   +2 more
openaire   +2 more sources

Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects

Advanced Functional Materials, EarlyView.
Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu, Jueun Kim, Dae‐Hyun Kim, Sewoom Baek, Suji Park, Seyong Chung, Hak‐Joon Sung   +6 more
wiley   +1 more source

Flexible Lipid Bilayers in Implicit Solvent

, 2005
A minimalist simulation model for lipid bilayers is presented. Each lipid is represented by a flexible chain of beads in implicit solvent. The hydrophobic effect is mimicked through an intermolecular pair potential localized at the ``water''/hydrocarbon ...
A. Ben-Shaul, D. Frenkel, D. Marsh, E. A. Evans, E. Sackmann, Frank L. H. Brown, Grace Brannigan, J. F. Nagle, J. Israelachvili, L. Rekvig, M. Bloom, M. Venturoli, Peter F. Philips, S. J. Marrink, U. Seifert   +14 more
core   +1 more source

Water permeation through stratum corneum lipid bilayers from atomistic simulations [PDF]

, 2009
Stratum corneum, the outermost layer of skin, consists of keratin filled rigid non-viable corneocyte cells surrounded by multilayers of lipids. The lipid layer is responsible for the barrier properties of the skin.
Bemporad, Berendsen, Berger, Blank, Bondi, Bouwstra, Chinmay Das, Chiu, Das, den Otter, Falck, Farwanah, Golden, Hara, Hoover, Hänggi, Höltje, Jacobson, Jorgensen, Kasting, Lodén, Mark, Marrink, Massimo G. Noro, Michaels, Miyamoto, Norlén, Norlén, Nosé, Nosé, Notman, Parrinello, Peter D. Olmsted, Pieper, Potts, Prausnitz, Ryckaert, Ryckaert, Schatzberg, Scheuplein, Schätzlein, Sugii, van der Spoel, Weerheim   +43 more
core   +2 more sources

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Dynamic Implicit-Solvent Coarse-Grained Models of Lipid Bilayer Membranes : Fluctuating Hydrodynamics Thermostat

, 2012
Many coarse-grained models have been developed for equilibrium studies of lipid bilayer membranes. To achieve in simulations access to length-scales and time-scales difficult to attain in fully atomistic molecular dynamics, these coarse-grained models ...
Atzberger, Paul J., Sigurdsson, Jon Karl, Wang, Yaohong   +2 more
core   +1 more source