Results 111 to 120 of about 1,227,492 (388)
PLoS Comput. Biol., 2014 Cell membranes are complex multicomponent systems, which are highly heterogeneous in the lipid distribution and composition. To date, most molecular simulations have focussed on relatively simple lipid compositions, helping to inform our understanding of
Heidi Koldsø +3 more
semanticscholar +1 more source
Cell Membrane Vesicle Camouflaged Artificial Cells
Advanced Functional Materials, EarlyView.Artificial cells camouflaged with a cell membrane vesicle coating are able to assemble into synthetic aggregates that exhibit rudimentary communication capabilities. Additionally, when these artificial cells are equipped with antioxidant capabilities, they are able to protect the intracellular homeostasis in HepG2 cells present in semi‐synthetic ...
Paula De Dios Andres +11 more
wiley +1 more source
, 2012 Many coarse-grained models have been developed for equilibrium studies of lipid bilayer membranes. To achieve in simulations access to length-scales and time-scales difficult to attain in fully atomistic molecular dynamics, these coarse-grained models ...
Atzberger, Paul J. +2 more
core +1 more source
Defect formation of lytic peptides in lipid membranes and their influence on the thermodynamic properties of the pore environment [PDF]
, 2006 We present an experimental study of the pore formation processes of small amphipathic peptides in model phosphocholine lipid membranes. We used atomic force microscopy to characterize the spatial organization and structure of alamethicin- and melittin ...
Binnig +51 more
core +2 more sources
Lipid Bilayer Curvature Frustration [PDF]
Biophysical Journal, 2013 The free energy of bending of surfaces composed of biological lipids is derived, computed, and compared with experiment. Simulations of two distinct systems, one a planar bilayer, the other the inverse hexagonal phase indicate consistent mechanical properties and curvature preferences, with DOPE having a spontaneous curvature, R0 = −26 Angstroms and ...
Alexander J. Sodt, Richard W. Pastor
openaire +2 more sources
Nature Materials, 2011 Encapsulation of drugs within nanocarriers that selectively target malignant cells promises to mitigate side effects of conventional chemotherapy and to enable delivery of the unique drug combinations needed for personalized medicine.
C. Ashley +20 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
Changes in single K+ channel behavior through the lipid phase transition [PDF]
, 2010 We show that the activity of an ion channel is strictly related to the phase state of the lipid bilayer hosting the channel. By measuring unitary conductance, dwell times, and open probability of the K+ channel KcsA as a function of temperature in lipid ...
Andrea Alessandrini +56 more
core +3 more sources
Biological Procedures Online, 1998 Planar lipid bilayers (PLB) were prepared by the Montal-Mueller technique in a FRAP system designed to simultaneously measure conductivity across, and lateral diffusion of, the bilayer.
Duclohier H +4 more
doaj +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source