Results 251 to 260 of about 125,587 (335)

Autophagy‐Mediated Suppression of Tumor Growth by Food‐Grade Lipid Nanoparticles in Mice

Advanced Science, EarlyView.
This work reveals a novel extracellular nanoparticle transport and metabolic pathway. Following cellular uptake, Food‐grade lipid nanoparticles (FLNs) selectively fuse with lipid droplets (LDs) rather than lysosomes, driving LDs accumulation. This process activates autophagy through the AMPK‐mTOR‐ULK1 signaling axis, facilitating tumor progression ...
Chenglu Peng, Bing Jiang, Wei Lu, Przemyslaw Zalewski, Jun He, Xiaoyang Li, Yiping Cao, Yiguo Zhao, Cuixia Sun, Katsuyoshi Nishinari, Yapeng Fang   +10 more
wiley   +1 more source

Quantitative single-molecule analysis of assembly and Ca²⁺-dependent disassembly of synaptotagmin oligomers on lipid bilayers. [PDF]

Commun Biol
Li F, Coleman J, Redondo-Morata L, Kalyana Sundaram RV, Stroeva E, Rothman JE, Pincet F.   +6 more
europepmc   +1 more source

Reassembly of protein-lipid complexes into large bilayer vesicles: Perspectives for membrane reconstitution

, 1980
Alberto Darszon, C A Vandenberg, Mordechay Schönfeld, Mark H. Ellisman, Nicholas C. Spitzer, M Montal   +5 more
openalex   +1 more source

Exosomal CMTM4 Induces Immunosuppressive Macrophages to Promote Ovarian Cancer Progression and Attenuate Anti‐PD‐1 Immunotherapy

Advanced Science, EarlyView.
In ovarian tumors with high CMTM4 expression, exosomes transfer CMTM4 to macrophages, upregulating ICAM1 and promoting M2 polarization via p65 nuclear translocation. This suppresses immunity by increasing PD‐1 and Tregs while reducing CD8+ T cells.
Bo Yin, Jianyi Ding, Jie Liu, Haoran Hu, Yashi Zhu, Meiqin Yang, Huijuan Zhou, Baoyou Huang, Tiefeng Huang, Mengjie Li, Yinyan He, Ang Li, Lingfei Han   +12 more
wiley   +1 more source

Free Energy, Rates, and Mechanism of Transmembrane Dimerization in Lipid Bilayers from Dynamically Unbiased Molecular Dynamics Simulations. [PDF]

J Phys Chem B
Jackel E, Lazzeri G, Covino R.
europepmc   +1 more source

Thermodynamic properties of the lipid bilayer transition. Pseudocritical phenomena

, 1983
Shigeki Mitaku, Toshiyo Jippo, Ryoichi Kataoka   +2 more
openalex   +1 more source

KRAS mRNA Spleen‐Targeting Lipid Nanoparticles Synergize with Irinotecan Silicasomes to Robustly Augment the Cancer Immunity Cycle in Pancreatic Cancer

Advanced Science, EarlyView.
To overcome pancreatic cancer's immunosuppressive barriers, this study explores a dual approach: triggering immunogenic tumor cell death at the primary tumor site with irinotecan‐loaded silicasomes and enhancing immune activation in the spleen using LNPs encapsulating tumor antigen mRNA and a TLR7/8 agonist.
Lijia Luo, Xiang Wang, Yu‐Pei Liao, Andre E. Nel   +3 more
wiley   +1 more source

Single-lipid tracking reveals heterogeneities in the nanoscale dynamics of colloid-supported lipid bilayers.

Soft Matter
Gascoigne L, Tas RP, Moerman PG, Voets IK.   +3 more
europepmc   +1 more source

Photophysics in Biomembranes: Computational Insight into the Interaction between Lipid Bilayers and Chromophores. [PDF]

Acc Chem Res
Osella S, Knippenberg S.
europepmc   +1 more source

The aggregation state of mellitin in lipid bilayers. An energy transfer study.

, 1986
Albin Hermetter, Joseph R. Lakowicz
openalex   +1 more source