Results 291 to 300 of about 125,587 (335)

Ligand Lipophilicity Determines Molecular Mechanisms of Nanoparticle Adsorption to Lipid Bilayers. [PDF]

ACS Nano
Huang-Zhu CA, Sheavly JK, Chew AK, Patel SJ, Van Lehn RC.   +4 more
europepmc   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Bioactive siRNA‐Based Liposomes Promoted Tendon‐Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248+ TSPCs

Advanced Science, EarlyView.
In this study, it is found that osteoporosis leads to disturbances in the Extracellular Matrix (ECM)of tendons and thus causes a decrease in TSPC stemness, resulting in a rotator cuff that is easily damaged and prone to retearing after repair. Targeted intervention with si‐CD248‐loaded liposomes can restore TSPC stemness, promote tendon‐bone healing ...
Yinhua Qian, Jinguo Zhu, Yanwei He, Haocheng Qin, Pingkang Qian, Bingfeng Sun, Haoqiang Huang, Chen Kuang, Quan Yang, Yuxi Ou, Rong Sun, Feng Xu, Xianwen Wang, Zhiwen Luo, Qing Wang   +14 more
wiley   +1 more source

Signatures of glassy dynamics in highly ordered lipid bilayers with emergence of soft dynamic channels

Sureshkumar H, Iyer S, Banerjee A, Poduval P, Lyman E, Srivastava A.   +5 more
europepmc   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Aggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong, Juan C. Mareque‐Rivas, Xinmiao Lan, Yu‐Xiong Su   +3 more
wiley   +1 more source

Mechanism of two styryl BODIPYs as fluorescent probes and protective agents in lipid bilayers against aqueous ClO. [PDF]

RSC Adv
Yang L, Jiang Y, Sun A, Chen M, Li Q, Wang P, Zhang J.   +6 more
europepmc   +1 more source

Lung‐Penetrating Biomimetic Extracellular Vesicle Spherical Nucleic Acids for Pulmonary Fibrosis Therapy Through ROS Scavenging and Anti‐Inflammatory Effects

Aggregate, EarlyView.
This work describes a biomimetic extracellular vesicle‐spherical nucleic acid (BEV‐SNA) platform for idiopathic pulmonary fibrosis (IPF) therapy. BEV‐SNA is composed of mechanically extruded BEVs from primary MSCs and cholesterol‐modified ssDNA that are assembled through hydrophobic interactions.
Saiyun Lou, Jiangpo Ma, Pan Fu, Lin Li, Jingyun Huang, Fangxue Jing, Yuhui Wang, Sihua Qian, Jianping Zheng, Jiang Li, Zhaoxing Dong, Kaizhe Wang   +11 more
wiley   +1 more source

Boosting the Antimicrobial Activity of Quaternary Ammonium Photosensitizers by Janus‐Type AIE Luminogens

Aggregate, EarlyView.
Novel quaternary ammonium AIE luminogens (AIEgens) with symmetric and Janus structures are rationally designed and prepared for bacteria killings. The integration of experimental and theoretical studies discloses that the Janus‐type AIEgen interacts better with bacterial membranes and shows stronger membrane perturbation, demonstrating superior ...
Dongyang Fan, Meng Li, Zipeng Shen, Ying Li, Jingjing Guo, Dong Wang, Ting Han, Ben Zhong Tang   +7 more
wiley   +1 more source

Supramolecular Probe for Monitoring Lysosomal Ferritinophagy to Facilitate the Early Diagnosis of Parkinson's Disease

Aggregate, EarlyView.
A supramolecular fluorescent probe, TPE‐4B/4Q[7], was designed to target lysosomes. The restriction of intramolecular rotation effect mediated by Q[7] enhances the fluorescence of TPE‐4B/4Q[7], enabling selective detection of Fe3+ with a detection limit of 1.23 × 10⁻⁶ M.
Shiqin Zhou, Bo Xiao, Jiamin Chen, Jinming Zhu, Xia Ran, Zuoji Liu, Chaozhong Li, Li Wang, Xinai Cui, Rong Li, Guangwei Feng, Jian Feng   +11 more
wiley   +1 more source