Results 121 to 130 of about 1,084,218 (302)

Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes [PDF]

, 2009
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the ...
A Fürstner, AP Davis, AV Koulov, C Yamamoto, D Stefayne, E Gout, ED Steinle, F Hofmeister, FA Norris, FG Riddell, HG Hempling, HM Florman, J Fujinaga, Jeffery T. Davis, JL Sessler, Jose Carlos Iglesias-Sánchez, JR Casey, JW Bennett, JY Choi, K Chang, K Kavallieratos, K Tanigaki, L You, M Nguyen, MS Melvin, NM Koropatkin, NN Gerber, NR Williamson, OA Okunola, Oluyomi A. Okunola, Philip A. Gale, Pilar Prados, PV Santacroce, RA Gottlieb, Roberto Quesada, S Ohkuma, T Sato, Tomás Torroba, V Rizzo, WN Lipscomb, WW Cleland, X Li   +41 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Elucidating the Lipid Binding Properties of Membrane-Active Peptides Using Cyclised Nanodiscs

Frontiers in Chemistry, 2019
The lipid composition of the cellular membrane plays an important role in a number of biological processes including the binding of membrane-active peptides.
Alan H. Zhang, Ingrid A. Edwards, Biswa P. Mishra, Gagan Sharma, Michael D. Healy, Alysha G. Elliott, Mark A. T. Blaskovich, Matthew A. Cooper, Brett M. Collins, Xinying Jia, Mehdi Mobli   +10 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition[S]

Journal of Lipid Research, 2017
Plasma apoC-III levels correlate with triglyceride (TG) levels and are a strong predictor of CVD outcomes. ApoC-III elevates TG in part by inhibiting LPL. ApoC-III likely inhibits LPL by competing for lipid binding.
Nathan L. Meyers, Mikael Larsson, Evelina Vorrsjö, Gunilla Olivecrona, Donald M. Small   +4 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation

Journal of Lipid Research, 2009
ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes. Here we
Ashley M. Vaughan, Chongren Tang, John F. Oram   +2 more
doaj   +1 more source

A Langmuir approach on monolayer interactions to investigate surface active peptides [PDF]

, 2010
The Langmuir Blodgett apparatus provides a versatile system for studying the interfacial properties of peptides and peptide-membrane interactions under controlled conditions.
Dennison, Sarah Rachel, Harris, Frederick, Phoenix, David Andrew   +2 more
core  

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source