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Lipid Droplets and Neurodegeneration
NeuroscienceEnergy metabolism in the brain has been considered one of the critical research areas of neuroscience for ages. One of the most vital parts of brain metabolism cascades is lipid metabolism, and fatty acid plays a crucial role in this process. The fatty acid breakdown process in mitochondria undergoes through a conserved pathway known as β-oxidation ...
Keya Mallick +3 more
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Distribution of Neutral Lipids in the Lipid Droplet Core
The Journal of Physical Chemistry B, 2014Cholesteryl esters (CEs) are a form of cholesterol (CHOL) storage in the living cells, as opposed to free CHOL. CEs are major constituents of low density lipoprotein particles. Therefore, CEs are implicated in provoking atherosclerosis. Arranged into cytoplasmic lipid droplets (LDs), CEs are stored intracellularly.
Chaban, Vitaly V, Khandelia, Himanshu
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DFCP1 associates with lipid droplets
Cell Biology International, 2019AbstractDouble FYVE‐containing protein 1 (DFCP1) is ubiquitously expressed, participates in intracellular membrane trafficking and labels omegasomes through specific interactions with phosphatidylinositol‐3‐phosphate (PI3P). Previous studies showed that subcellular DFCP1 proteins display multi‐organelle localization, including in the endoplasmic ...
Guangang, Gao +4 more
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Analysis of Biogenesis of Lipid Droplets by Examining Rab40c Associating with Lipid Droplets
2014The biogenesis of lipid droplets (LDs) is regulated by multiple proteins. Rab40c is a recently characterized small GTPase associating with LDs. Here we describe our approaches to analyze the involvement of Rab40c in the biogenesis of LDs. Co-localization of Rab40c and LDs was revealed through fluorescence confocal microscopy by expressing GFP-Rab40c ...
Ran, Tan +3 more
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Cytoskeleton regulates lipid droplet fusion and lipid storage by controlling lipid droplet movement
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsLipid droplets (LDs) are highly dynamic organelles that maintain cellular lipid homeostasis through size and number control. In adipose tissue, CIDEC plays a crucial role in LD fusion and lipid homeostasis. However, the regulatory factors and mechanisms of LD fusion remain largely unknown.
Yan, Liang +11 more
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Lipid droplets in inflammation and cancer
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2010Accumulation of lipid droplets (also known as lipid bodies or adiposomes) within leukocytes, epithelial cells, hepatocytes and other non-adipocytic cells is a frequently observed phenotype in infectious, neoplastic and other inflammatory conditions. Lipid droplet biogenesis is a regulated cellular process that culminates in the compartmentalization of ...
Patricia T, Bozza, João P B, Viola
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Lipid Droplet in Lipodystrophy and Neurodegeneration
Biology of the CellABSTRACTLipid droplets are ubiquitous yet distinct intracellular organelles that are gaining attention for their uses outside of energy storage. Their formation, role in the physiological function, and the onset of the pathology have been gaining attention recently.
Priyatama, Behera, Monalisa, Mishra
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Abstract Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids to meet cellular energetic and signaling needs. As a unique monolayer structure, LDs arise from the endoplasmic reticulum (ER) and acquire proteins and lipids through their membrane contact sites (MCSs) with the ER.
Miner, Gregory E. +2 more
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Miner, Gregory E. +2 more
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Lipid Droplets: Packing Hydrophobic Molecules Within the Aqueous Cytoplasm
Annual Review of Plant Biology, 2023Kent D Chapman +2 more
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Adipocyte-Derived Anticancer Lipid Droplets
Advanced Materials, 2021Zhaowei Chen, Hong-Jun Li, Guojun Chen
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