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Lipid Droplets in Disease [PDF]
Cells, 2019 Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular ...
Paul Dalhaimer
doaj +3 more sources
A Review of Diatom Lipid Droplets [PDF]
Biology, 2020 The dynamic nutrient availability and photon flux density of diatom habitats necessitate buffering capabilities in order to maintain metabolic homeostasis. This is accomplished by the biosynthesis and turnover of storage lipids, which are sequestered in lipid droplets (LDs).
Ben Leyland +2 more
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Dynamics and functions of lipid droplets [PDF]
Nature Reviews Molecular Cell Biology, 2018 Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins.
James Olzmann, Pedro Carvalho
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Volumetric analysis of lymphocyte lipid droplets in type 2 diabetes mellitus patients with hyperlipidemia [PDF]
Medicinski Podmladak, 2023 Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by inadequate glucose homeostasis. A common occurrence of T2DM is diabetic dyslipidemia.
Živković Aleksa +4 more
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Small GTPase Rab40c associates with lipid droplets and modulates the biogenesis of lipid droplets. [PDF]
PLoS ONE, 2013 The subcellular location and cell biological function of small GTPase Rab40c in mammalian cells have not been investigated in detail. In this study, we demonstrated that the exogenously expressed GFP-Rab40c associates with lipid droplets marked by ...
Ran Tan +10 more
doaj +1 more source
STAR Protocols, 2022 Summary: Here, we present a protocol to construct artificial lipid droplets to study the binding affinity of lipid droplet-associated proteins. We provide procedures to construct adiposomes and prepare recombinant lipid droplet-associated proteins.
Zelun Zhi +5 more
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Lipid droplet metabolism [PDF]
Current Opinion in Clinical Nutrition and Metabolic Care, 2013 With the realization that lipid droplets are not merely inert fat storage organelles, but highly dynamic and actively involved in cellular lipid homeostasis, there has been an increased interest in lipid droplet biology. Recent studies have begun to unravel the roles that lipid dropletss play in cellular physiology and provide insights into the ...
Victor K, Khor +2 more
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Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.
PLoS Genetics, 2021 Fat stored in the form of lipid droplets has long been considered a defining characteristic of cytoplasm. However, recent studies have shown that nuclear lipid droplets occur in multiple cells and tissues, including in human patients with fatty liver ...
Jose Verdezoto Mosquera +2 more
doaj +1 more source
Trends in Cell Biology, 2021 All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets, surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid metabolism and function in diverse biological processes. During the past decade, multidisciplinary approaches have shed light on LD assembly steps from the endoplasmic ...
Thiam, Abdou Rachid, Ikonen, Elina
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Lipid Droplet Biogenesis [PDF]
Annual Review of Cell and Developmental Biology, 2017 Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis.
Tobias C, Walther +2 more
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