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Lipid Droplets in Cancer [PDF]
, 2020 AbstractLipid droplets have a unique structure among organelles consisting of a dense hydrophobic core of neutral lipids surrounded by a single layer of phospholipids decorated with various proteins. Often labeled merely as passive fat storage repositories, they in fact have a remarkably dynamic life cycle. Being formed within the endoplasmic reticulum
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Effect of substrates on the cyclic AMP-dependent lipolytic reaction of hormone-sensitive lipase.
Journal of Lipid Research, 1994 Cyclic AMP-dependent activation of hormone-sensitive lipase (HSL) stimulated lipolysis of [3H]triolein emulsified with gum arabic, but not that of endogenous lipid droplets from rat fat cells.
H Okuda, C Morimoto, T Tsujita
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Lipid Droplets and Cellular Lipid Metabolism [PDF]
Annual Review of Biochemistry, 2012 Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism. In addition, LDs are implicated in a number of other cellular functions, ranging from protein storage ...
Tobias C, Walther, Robert V, Farese
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Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.
Journal of Lipid Research, 1995 Immunocytochemistry was used to determine the intracellular location of perilipins in adipocytes and the occurrence of these proteins in tissues involved in triacylglycerol metabolism.
E.J. Blanchette-Mackie +8 more
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Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans
iScience, 2023 Summary: In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated intestinal lipid stores, but their role in longevity is unclear.
Anita V. Kumar +11 more
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Cell, 2009 Lipid droplets (LDs) are universal cellular organelles that specialize in the storage of neutral lipids, such as sterol esters and triacylglycerols (see Essay by Farese and Walther, this issue). As such, they provide the main cellular reservoir for lipids of energy storage and membrane synthesis, and they protect cells from the lipotoxic effects of ...
Krahmer, N. +3 more
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On the lifetimes of evaporating droplets [PDF]
, 2014 The complete description of the lifetime of a droplet on a solid substrate evaporating in a 'stick–slide' mode is obtained. The unexpectedly subtle relationship between the lifetime of such a droplet and the lifetimes of initially identical droplets ...
Wilson, S. K. +3 more
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Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. [PDF]
PLoS ONE, 2015 Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins.
Joseph D Love +7 more
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TIP47 Is Not a Component of Lipid Droplets [PDF]
Journal of Biological Chemistry, 2001 TIP47 functions in the delivery of mannose 6-phosphate receptors from endosomes to the trans-Golgi network both in vitro and in vivo. It binds directly and very specifically to the cytoplasmic domains of both the cation-independent and cation-dependent mannose 6-phosphate receptors.
Barbero, Pierre +3 more
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Journal of Lipid Research, 2010 Caveolins form plasmalemnal invaginated caveolae. They also locate around intracellular lipid droplets but their role in this location remains unclear. By studying primary adipocytes that highly express caveolin-1, we characterized the impact of caveolin-
Cédric M. Blouin +12 more
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