Results 21 to 30 of about 98,017 (217)

Candidate genes responsible for lipid droplets formation during adipogenesis simultaneously affect osteoblastogenesis

Folia Histochemica et Cytobiologica, 2022
INTRODUCTION: With cellular lipid storage varying, the balance between lipid intake and lipid degradation was a must to keep healthy and determined the level of lipid droplets. Although lipid droplets accumulation had been well demonstrated in adipocytes,
Xia Yi, Ping Wu, Ying Gong, Jianyun Liu, Jianjun Xiong, Xiangxin Che, Xiaoyuan Xu   +6 more
doaj   +1 more source

Lipid droplets in the nervous system: involvement in cell metabolic homeostasis

Neural Regeneration Research
Lipid droplets serve as primary storage organelles for neutral lipids in neurons, glial cells, and other cells in the nervous system. Lipid droplet formation begins with the synthesis of neutral lipids in the endoplasmic reticulum.
Yuchen Zhang, Yiqing Chen, Cheng Zhuang, Jingxuan Qi, Robert Chunhua Zhao, Jiao Wang   +5 more
doaj   +1 more source

Identification of the lipid droplet targeting domain of the Cidea protein[S]

Journal of Lipid Research, 2010
Cidea, the cell death-inducing DNA fragmentation factor-α-like effector (CIDE) domain-containing protein, is targeted to lipid droplets in mouse adipocytes, where it inhibits triglyceride hydrolysis and promotes lipid storage.
Jennifer L. Christianson, Emilie Boutet, Vishwajeet Puri, Anil Chawla, Michael P. Czech   +4 more
doaj   +1 more source

Application of synthetic lipid droplets in metabolic diseases

Clinical and Translational Medicine, 2023
Background The study and synthesis of membrane organelles are becoming increasingly important, not only as simplified cellular models for corresponding molecular and metabolic studies but also for applications in synthetic biology of artificial cells and
Pengxiang Zhao, Zichen Zhao, Ziwei Yu, Lupeng Chen, Yi Jin, Jian Wu, Zhuqing Ren   +6 more
doaj   +1 more source

Asymmetrical Illumination Enables Lipid Droplets Segmentation in Caenorhabditis elegans Using Epi-Illumination Dark Field Microscopy

Frontiers in Physics, 2022
Lipid droplets are the major organelles for fat storage in a cell and analyzing lipid droplets in Caenorhabditis elegans (C. elegans) can shed light on obesity-related diseases in humans.
Ruijie Shi, Yu Sun, Jingde Fang, Xiangyang Chen, Zachary J. Smith, Zachary J. Smith, Kaiqin Chu, Kaiqin Chu   +7 more
doaj   +1 more source

Rab32 is important for autophagy and lipid storage in Drosophila. [PDF]

PLoS ONE, 2012
Lipids are essential components of all organisms. Within cells, lipids are mainly stored in a specific type of organelle, called the lipid droplet. The molecular mechanisms governing the dynamics of lipid droplets have been little explored.
Chao Wang, Zhonghua Liu, Xun Huang
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Triglyceride depletion in THP-1 cells alters cholesteryl ester physical state and cholesterol efflux

Journal of Lipid Research, 2002
To study macrophage lipid droplet composition and the effects of TG on cholesteryl ester (CE) physical state, hydrolysis, and cholesterol efflux, a technique was developed to remove the majority of accumulated TG with minimal effect on CE content.
Aaron T. Lada, Mark C. Willingham, Richard W. St. Clair   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source