Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation [PDF]
Virology JournalBackground Viruses critically depend on host lipid metabolism to drive replication, assembly and immune evasion during infection and pathogenesis. While previous studies have demonstrated that certain viruses induce lipid droplet accumulation in infected
Xiaohui Yang +7 more
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Lipid droplet distribution quantification method based on lipid droplet detection by constrained reinforcement learning. [PDF]
PLoS ONEWe previously proposed the lipid droplet detection by reinforcement learning (LiDRL) method using a limited dataset of pathological images. The method automatically detects lipid droplets using reinforcement learning to optimize filter combinations based
Yoshitomi Harada +2 more
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Transcriptomic Analysis of High and Low Lipid Droplet Deposition Subpopulations of Chicken Preadipocytes Based on SSC Sorting [PDF]
AnimalsFat deposition plays a crucial role in regulating the production performance and meat quality of broilers. Although the heterogeneity of mammalian adipocytes has been extensively studied, research on the molecular mechanisms underlying differences in ...
Boyu Wang +6 more
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Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution [PDF]
Advanced ScienceLipid droplets (LDs) are central to cellular energy homeostasis and lipid metabolism. While LD‐associated proteins are known to regulate LD dynamics and function, their roles in LD transport and their broader cellular significance remain poorly ...
Honggang Su +10 more
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C18ORF32 modulates lipid droplet secretion via secretory autophagy and restrains hepatic steatosis in vivo [PDF]
Cell Communication and SignalingBackground Lipid droplets (LDs) are essential for maintaining cellular homeostasis by storing excess lipids, but regulation of their cellular level is crucial to prevent lipotoxicity under normal conditions.
Abhishek Kumar +3 more
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Monoubiquitination of ancient ubiquitous protein 1 promotes lipid droplet clustering. [PDF]
PLoS ONE, 2013 Lipid droplets, the intracellular storage organelles for neutral lipids, exist in a wide range of sizes and of morphologically distinct organization, from loosely dispersed lipid droplets to tightly packed lipid droplet clusters.
Daniel Lohmann +5 more
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STAR Protocols, 2022 Summary: Here, we present a protocol to construct artificial lipid droplets to study the binding affinity of lipid droplet-associated proteins. We provide procedures to construct adiposomes and prepare recombinant lipid droplet-associated proteins.
Zelun Zhi +5 more
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Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication
Frontiers in Physiology, 2022 A variety of pathogens, including viruses, bacteria and parasites, target cellular lipid droplets for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and are a major cause of acute gastroenteritis in infants and ...
Jeanette M. Criglar +3 more
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Frontiers in Nutrition, 2022 Intermittent fasting is one of the most common clinical treatments for the obesity, a main risk factor of the metabolic syndrome which can lead to a variety of diseases.
Hongqiang Li +8 more
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The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly.
PLoS Pathogens, 2020 Lipid droplets are essential cellular organelles for storage of fatty acids and triglycerides. The hepatitis C virus (HCV) translocates several of its proteins onto their surface and uses them for production of infectious progeny.
Gabrielle Vieyres +4 more
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