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HOPS and Vps13 Have Antagonistic Roles in Regulating Lipid Droplet Morphology [PDF]
CellsLipid droplets are dynamic organelles that store neutral lipids (mostly triacylglycerols and sterol esters) and are bound by a single phospholipid monolayer.
Jie Wang +6 more
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Identification of TMEM263 as an ER-resident protein that controls early stages of lipid droplet biogenesis [PDF]
Nature CommunicationsCell and organismal growth is controlled not only by the availability of nutrients, but also the ability to dynamically sense and respond to changes in metabolic demand. We have identified a protein, TMEM263 (also known as C12orf23) as a mechanistic link
Katy Yalci +12 more
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APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics [PDF]
Nature CommunicationsLipid droplets are dynamic cellular organelles that store neutral lipids and coordinate metabolic and stress-response pathways. In the brain, lipid droplets in glial cells, including astrocytes, have been implicated in Alzheimer’s disease, but how ...
Carla Cuní-López +16 more
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Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution [PDF]
Advanced ScienceLipid droplets (LDs) are central to cellular energy homeostasis and lipid metabolism. While LD‐associated proteins are known to regulate LD dynamics and function, their roles in LD transport and their broader cellular significance remain poorly ...
Honggang Su +10 more
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Lipid droplet distribution quantification method based on lipid droplet detection by constrained reinforcement learning. [PDF]
PLoS ONEWe previously proposed the lipid droplet detection by reinforcement learning (LiDRL) method using a limited dataset of pathological images. The method automatically detects lipid droplets using reinforcement learning to optimize filter combinations based
Yoshitomi Harada +2 more
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microPublication Biology, 2023 Our experiments aim to determine if decreasing the amount of phosphatidylcholine (PC) relative to phosphatidylethanolamine (PE) at the lipid droplet surface changes the localization of specific lipid droplet proteins.
Timothy J. Renier +8 more
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Monoubiquitination of ancient ubiquitous protein 1 promotes lipid droplet clustering. [PDF]
PLoS ONE, 2013 Lipid droplets, the intracellular storage organelles for neutral lipids, exist in a wide range of sizes and of morphologically distinct organization, from loosely dispersed lipid droplets to tightly packed lipid droplet clusters.
Daniel Lohmann +5 more
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STAR Protocols, 2022 Summary: Here, we present a protocol to construct artificial lipid droplets to study the binding affinity of lipid droplet-associated proteins. We provide procedures to construct adiposomes and prepare recombinant lipid droplet-associated proteins.
Zelun Zhi +5 more
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Frontiers in Nutrition, 2022 Intermittent fasting is one of the most common clinical treatments for the obesity, a main risk factor of the metabolic syndrome which can lead to a variety of diseases.
Hongqiang Li +8 more
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Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication
Frontiers in Physiology, 2022 A variety of pathogens, including viruses, bacteria and parasites, target cellular lipid droplets for their replication. Rotaviruses (RVs) infect the villous epithelium of the small intestine and are a major cause of acute gastroenteritis in infants and ...
Jeanette M. Criglar +3 more
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