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Lipid Droplets in Disease [PDF]
Cells, 2019 Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular disease, and cancer [...]
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A Review of Diatom Lipid Droplets [PDF]
Biology, 2020 The dynamic nutrient availability and photon flux density of diatom habitats necessitate buffering capabilities in order to maintain metabolic homeostasis. This is accomplished by the biosynthesis and turnover of storage lipids, which are sequestered in lipid droplets (LDs).
Ben Leyland +2 more
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Dynamics of Vesicle Formation from Lipid Droplet: Mechanism and Controllability
, 2009 A coarse-grained model developed by Marrink et al. [J. Phys. Chem. B 111, 7812 (2007)] is applied to investigate vesiculation of lipid [dipalmitoylphosphatidylcholine (DPPC)] droplets in water.
Helfrich W., Xuehao He, Zilu Wang
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COPI complex is a regulator of lipid homeostasis.
PLoS Biology, 2008 Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin,
Mathias Beller +6 more
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The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System. [PDF]
PLoS ONE, 2016 Chronic infection with the hepatitis C virus frequently induces steatosis, which is a significant risk factor for liver pathogenesis. Steatosis is characterized by the accumulation of lipid droplets in hepatocytes.
Shingo Iwasa +7 more
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Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells
AnimalsFat deposition plays a key role in determining porcine meat quality traits, with lipid droplets serving as critical organelles for lipid storage in adipose tissue. Inhibiting lipid droplet biogenesis disrupts the lipid storage capacity of adipocytes. The
Wenzhe Bai +7 more
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FEBS LettersLipid droplets (LDs) are intracellular organelles with a hydrophobic core formed by neutral lipids surrounded by a phospholipid monolayer harboring a variety of regulatory and enzymatically active proteins. Over the last few decades, our understanding of LD biology has evolved significantly.
Michele Wölk, Maria Fedorova
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The Gregarious Lipid Droplet [PDF]
Journal of Biological Chemistry, 2008 Cytoplasmic lipid droplets were considered until recently to be in the same category as glycogen granules, simple storage sites for energy, waxing and waning as metabolic energy needs dictated, but otherwise inert particles. It has become clear, however, that droplets are much more than isolated storage depots in the cell and that they can skate around
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Lipid droplets in stress protection: distinct mechanisms of lipid droplet microautophagy
Autophagy Reports, 2022 Lipid droplets (LDs) are organelles that function as sites for lipid storage. LDs have also been implicated in the cellular response to proteotoxic or lipotoxic stress as sites for sequestering dysfunctional or excess proteins or lipids, and targeting those cargos for degradation by LD microautophagy (microlipophagy, μLP).
Pin-Chao Liao, Liza A. Pon
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TFAP2 transcription factors are regulators of lipid droplet biogenesis
eLife, 2018 How trafficking pathways and organelle abundance adapt in response to metabolic and physiological changes is still mysterious, although a few transcriptional regulators of organellar biogenesis have been identified in recent years.
Cameron C Scott +3 more
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