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FEBS LettersLipid droplets (LDs) are intracellular organelles with a hydrophobic core formed by neutral lipids surrounded by a phospholipid monolayer harboring a variety of regulatory and enzymatically active proteins. Over the last few decades, our understanding of LD biology has evolved significantly.
Michele Wölk, Maria Fedorova
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The Gregarious Lipid Droplet [PDF]
Journal of Biological Chemistry, 2008 Cytoplasmic lipid droplets were considered until recently to be in the same category as glycogen granules, simple storage sites for energy, waxing and waning as metabolic energy needs dictated, but otherwise inert particles. It has become clear, however, that droplets are much more than isolated storage depots in the cell and that they can skate around
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Electrodynamic droplet actuation for lab on a chip system
, 2011 This work presents the development of electrowetting on dielectric and liquid dielectrophoresis as a platform for chemistry, biochemistry and biophysics.
Aghdaei, Sara
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Current Opinion in Cell Biology, 2019 Lipid droplets (LDs) store neutral lipids in their core as an energy source when nutrients are scarce. The center of an LD is hydrophobic, and hence it is surrounded by a phospholipid monolayer, unlike other organelles that have an aqueous interior and are bounded by a phospholipid bilayer.
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Exploiting lipid droplet metabolic pathway to foster lipid production: oleosin in focus [PDF]
In the past decade, there has been an emerging gap between the demand and supply of vegetable oils globally for both edible and industrial use. Lipids are important biomolecules with enormous applications in the industrial sector and a major source of ...
Sinha, K. +3 more
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Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. [PDF]
PLoS ONE, 2015 Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins.
Joseph D Love +7 more
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, 2012 Lipid droplet intermediates have recently been described in the fission yeast Schizosaccharomyces pombe (please see link below). These intermediates arise from fission and fusion events, and presumably occur during lipid droplet biogenesis, degradation ...
Ethan Perlstein (97610) +1 more
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COPI complex is a regulator of lipid homeostasis.
PLoS Biology, 2008 Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet formation and regulation, it is clear that members of the PAT (perilipin,
Mathias Beller +6 more
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Lipid Droplets in Neurodegenerative Disorders [PDF]
Frontiers in Neuroscience, 2020 Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to dynamic and functionally active organelles involved in a variety of cellular functions. Studies have now informed significant roles for LDs in cellular signaling, metabolic disease, and inflammation.
Brandon C. Farmer +4 more
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, 2012 We observe diversity of lipid droplet morphology in yeast cells treated with the SSRI antidepressant sertraline/Zoloft, including lipid droplet fusion, fisson and assimllation into organelles involved in vesicle transport.
Ethan Perlstein (97610) +1 more
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