Results 61 to 70 of about 870,619 (302)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation [PDF]

, 2020
Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the development of obesity-induced adipose ...
Weeghel, Michel, van, Singh, Rajat, Georgiadi, Anastasia, Mattijssen, Frits, Rosa Rodriguez, Montserrat A., de la, Stienstra, Rinke, Borst, Jan Willem, Dierendonck, Xanthe A.M.H., van, Dijk, Wieneke, Kersten, Sander, Stienstra, R., Rajat Singh, de La Rosa Rodriguez, Montserrat, Rinke Stienstra, Jan Willem Borst, Montserrat A. de la Rosa Rodriguez, Michel van Weeghel, Wieneke Dijk, van Weeghel, Michel, Anastasia Georgiadi, Frits Mattijssen, Sander Kersten, Weeghel, Michel van, Rosa Rodriguez, Montserrat A. de la, van Dierendonck, Xanthe A.M.H., Dierendonck, X. van, Xanthe A.M.H. van Dierendonck   +26 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation

Virology Journal
Background Viruses critically depend on host lipid metabolism to drive replication, assembly and immune evasion during infection and pathogenesis. While previous studies have demonstrated that certain viruses induce lipid droplet accumulation in infected
Xiaohui Yang, Haiwen Zhong, Chuanzhao Yu, Jie Cheng, Huijie Jiang, Cuizhen Wang, Changxu Song, Huaqiang Yang   +7 more
doaj   +1 more source

Lipid Droplets as Organelles [PDF]

, 2018
Long considered inert fat storage depots, it has become clear that lipid droplets (LDs) are bona fide organelles. Like other organelles, they have a characteristic complement of proteins and lipids, and undergo a life cycle that includes biogenesis, maturation, interactions with other organelles, and turnover.
openaire   +2 more sources

Experimental results of detection in lipid droplet dataset.

, 2018
Experimental results of detection in lipid droplet dataset.
Kazuhiro Hotta (2026225), Kenshiro Nishida (5843192)   +1 more
core   +1 more source

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology. [PDF]

, 2022
Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid ...
Farese, R.V., Boland, S., Burtt, N.P., Song, J., Frendo-Cumbo, S., Costanzo, M.C., Olzmann, J.A., Mejhert, N., Kuruvilla, L., Flannick, J., von Grotthuss, M., Gabriel, K.R., Jang, D.K., Rydén, M., Krahmer, N., Chitraju, C., Chitraju, Chandramohan, Krahmer, Natalie, Chitraju, C, Costanzo, Maria C., Jang, Dong-Keun, Gabriel, Katlyn R., von, Grotthuss M, Song, Jiunn, Farese, Robert V., Burtt, Noël P., Gabriel, KR, Mejhert, N,, Boland, S, von Grotthuss, Marcin, Rydén, Mikael, Krahmer, N, Mejhert, Niklas, Kuruvilla, L, Frendo-Cumbo, S, Flannick, Jason, Walther, Tobias C, Frendo-Cumbo, Scott, Farese, Robert V, Song, J, Olzmann, James A., Walther, Tobias C., Gabriel, Katlyn R, Olzmann, James A, Costanzo, Maria C, Burtt, Noël P, Boland, Sebastian, Jang, D-K, Kuruvilla, Leena, Jiunn Song, Marcin von Grotthuss, Noël P. Burtt, Katlyn R. Gabriel, Mikael Rydén, Robert V. Farese, Leena Kuruvilla, Natalie Krahmer, Tobias C. Walther, Jason Flannick, Niklas Mejhert, Dong-Keun Jang, Sebastian Boland, James A. Olzmann, Scott Frendo-Cumbo, Maria C. Costanzo, Chandramohan Chitraju   +65 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Regulation of Lipid-Droplet Transport by the Perilipin Homolog LSD2

, 2005
SummaryBackground: Motor-driven transport along microtubules is a primary mechanism for moving and positioning organelles. How such transport is regulated remains poorly understood.
Griner, John, Viera, Arturo, Guo, Yi, Welte, Michael A., Kim, Dae-Hwan, Gindhart, Joseph G., Gross, Steven P., Cermelli, Silvia   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source