Results 81 to 90 of about 870,619 (302)

Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites

Nature Communications
Membrane contact sites between organelles are critical for the transfer of biomolecules. Lipid droplets store fatty acids and form contacts with mitochondria, which regulate fatty acid oxidation and adenosine triphosphate production.
Ayenachew Bezawork-Geleta, Camille J. Devereux, Stacey N. Keenan, Jieqiong Lou, Ellie Cho, Shuai Nie, David P. De Souza, Vinod K. Narayana, Nicole A. Siddall, Carlos H. M. Rodrigues, Stephanie Portelli, Tenghao Zheng, Hieu T. Nim, Mirana Ramialison, Gary R. Hime, Garron T. Dodd, Elizabeth Hinde, David B. Ascher, David A. Stroud, Matthew J. Watt   +19 more
doaj   +1 more source

Riboflavin-photosensitized lipid oxidation in oil-in-water nanoemulsions: effects of oxygen scavengers and metal chelator

Frontiers in Nutrition
This study examined how droplet size affects riboflavin-photosensitized lipid oxidation in oil-in-water emulsions and evaluated the roles of sodium azide (SA), superoxide dismutase (SOD), and ethylenediaminetetraacetic acid (EDTA) under light exposure. A
Fatma Bozanoglu, Sibel Uluata, Gokhan Durmaz   +2 more
doaj   +1 more source

Characterization of the Drosophila lipid droplet subproteome. [PDF]

, 2006
Lipid storage droplets are universal organelles essential for the cellular and organismal lipometabolism including energy homeostasis. Despite their apparently simple design they are proposed to participate in a growing number of cellular processes ...
Kuehnlein, R., Kühnlein, Ronald P, Dieterich, Guido, Jaeckle, H., Beller, M., Riedel, D., Jäckle, Herbert, Wehland, Jürgen, Jänsch, Lothar, Beller, Mathias, Jaensch, L., Dieterich, G., Riedel, Dietmar, Wehland, J.   +13 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

Nature Communications, 2021
Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation by ...
Yoel A. Klug, Justin C. Deme, Robin A. Corey, Mike F. Renne, Phillip J. Stansfeld, Susan M. Lea, Pedro Carvalho   +6 more
doaj   +1 more source

The life cycle of lipid droplets [PDF]

Current Opinion in Cell Biology, 2015
Proteomic studies have revealed many potential functions of cytoplasmic lipid droplets, and recent activity has confirmed that these bona fide organelles are central not only for lipid storage and metabolism, but for development, immunity, and pathogenesis by several microbes.
Hayaa F, Hashemi, Joel M, Goodman
openaire   +2 more sources

Tensing Up for Lipid Droplet Formation

, 2017
Lipid droplets are fat storage organelles in cells that physically resemble stable oil-water emulsion droplets. In this issue of Developmental Cell, Ben M'barek et al.
Roux, Aurélien, Robbie Loewith, Loewith, Robbie Joséph, Aurélien Roux, Roux A, Loewith R   +5 more
core   +1 more source

ATG14 plays a critical role in hepatic lipid droplet homeostasis

, 2023
Background & aims: Autophagy-related 14 (ATG14) is a key regulator of autophagy. ATG14 is also localized to lipid droplet; however, the function of ATG14 on lipid droplet remains unclear.
Huang, Menghao, Park, Jimin, Burcin Ekser, Yu, Liqing, Kushan Chowdhury, Alex Lu, Zhang, Wenjun, Jimin Park, Zhang, Yang, Lu, Alex, Yang Zhang, Lu Wang, Xu, Jiazhi, Ekser, Burcin, Chowdhury, Kushan, Wang, Lu, Liqing Yu, Menghao Huang, X. Charlie Dong, Wenjun Zhang, Dong, X. Charlie, Jiazhi Xu   +21 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source