Results 101 to 110 of about 870,619 (302)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Potential applications of lipid droplets from marine plants and microalgae in food and health

Food Chemistry Advances
Lipid droplets serve as an essential storage energy, well known to exist in plants. Lipid droplets have been observed in seagrass, diatoms, and microalgae.
Buntora Pasaribu, Alifannursin M. Atsarak, Lantun P. Dewanti, Yuniarti MS․, Syawaludin A. Harahap, Pringgo D.K.N.Y. Putra, Lady A. Sriwijayanti, Arif S.W. Kusuma, Rizky Abdulah, Alvita Karina Putri, Jogi R.N. Panggabean, Yeni Mulyani, Neng T. Sofyana, Tonni A. Kurniawan, Yunita E. Puspitasari   +14 more
doaj   +1 more source

TRAPPing Rab18 in lipid droplets

The EMBO Journal, 2017
Abstract A number of membrane trafficking components are associated with lipid droplets (LDs) and/or are involved in their biogenesis. In this issue of The EMBO Journal , Li et al (2017) show that the mammalian TRAPPII (TRAnsport ...
Zappa, Francesca, Venditti, Rossella, DE MATTEIS, Maria Antonietta   +2 more
openaire   +3 more sources

Antioxidant Clove Extract Inhibits Lipid Droplet Accumulation and Lipid Oxidation in Hepatocytes

Background: Recent studies have shown that plant-based dietary extracts can prevent the formation of lipid droplets (LDs) and oxidized lipid droplets (oxLDs) in liver cells.
Dibwe, Dya Fita, Monde, Satomi, Hui, Shu-Ping, Iwasaki, Shion, Satomi Monde, Dya Fita Dibwe, Shu-Ping Hui, Shion Iwasaki   +7 more
core   +1 more source

Peroxisomal Components Function to Regulate Lipolysis at the Lipid Droplet Surface

, 2019
Organelles serve to compartmentalize biochemical functions within the eukaryotic cell. However, to collectively maintain cellular homeostasis, organelles must communicate in some way in order to coordinate these functions.
Anderson-Baron, Matthew N
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Lipid droplets [PDF]

Current Biology, 2008
Listenberger, Laura L., Brown, Deborah A.   +1 more
openaire   +2 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Alkyl gallates disrupt Trypanosoma brucei lipid droplets.

PLoS ONE
African trypanosomiasis is a deadly disease that affects humans and animals, with treatment hindered by drug toxicity and resistance, highlighting the need for alternative therapies.
Cynthia Mmalebna Amisigo, Gloria Amegatcher, Jack D Sunter, Theresa Manful Gwira   +3 more
doaj   +1 more source

Lactate alleviates early brain damage after subarachnoid hemorrhage: Regulation of lipid metabolism

Neural Regeneration Research
This study investigated the neuroprotective effects of lactate in subarachnoid hemorrhage, a severe cerebrovascular disease that is commonly caused by arterial aneurysm rupture and has limited early treatment options.
Zichen Zhang, Xinan Li, Xiaoli Liu, Lei Chen, Yunzhi Wang, Enyan Jiang, Jia Zeng, Xiaojian Zhang, Zhen Fang, Zibin Liang, Jikai Wang, Fei Liu   +11 more
doaj   +1 more source