Results 31 to 40 of about 870,619 (302)
Lipid Droplet Accumulation Promotes RPE Dysfunction
, 2022 Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of retinal pigment epithelium (RPE).
Tomohiro Yako +4 more
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Lipid Droplets in Health and Disease [PDF]
Lipids in Health and Disease, 2017 Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals. They are composed of a hydrophobic neutral lipid core surrounding by a phospholipid monolayer membrane with various decorating ...
Gizem Onal +3 more
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Functions of Stress-Induced Lipid Droplets in the Nervous System
Frontiers in Cell and Developmental Biology, 2022 Lipid droplets are highly dynamic intracellular organelles that store neutral lipids such as cholesteryl esters and triacylglycerols. They have recently emerged as key stress response components in many different cell types. Lipid droplets in the nervous
Eva Islimye +2 more
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Lipid Droplets in Disease [PDF]
Cells, 2019 Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular disease, and cancer [...]
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The lipase cofactor CGI58 controls placental lipolysis
JCI Insight, 2023 In eutherians, the placenta plays a critical role in the uptake, storage, and metabolism of lipids. These processes govern the availability of fatty acids to the developing fetus, where inadequate supply has been associated with substandard fetal growth.
Jennifer Guerrero-Santoro +11 more
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Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death
Frontiers in Cell and Developmental Biology, 2023 Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic kingdom. They have a central role in regulating lipid metabolism and undergo a dynamic turnover of biogenesis and breakdown to meet cellular requirements for fatty ...
Mauro Danielli +3 more
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Lipid droplets in stress protection: distinct mechanisms of lipid droplet microautophagy
Autophagy Reports, 2022 Lipid droplets (LDs) are organelles that function as sites for lipid storage. LDs have also been implicated in the cellular response to proteotoxic or lipotoxic stress as sites for sequestering dysfunctional or excess proteins or lipids, and targeting those cargos for degradation by LD microautophagy (microlipophagy, μLP).
Pin-Chao Liao, Liza A. Pon
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A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
Frontiers in Chemistry, 2021 Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biological processes, which could be a potential target site for photodynamic therapy (PDT) of cancer.
Xiang Xia +9 more
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A Review of Diatom Lipid Droplets [PDF]
Biology, 2020 The dynamic nutrient availability and photon flux density of diatom habitats necessitate buffering capabilities in order to maintain metabolic homeostasis. This is accomplished by the biosynthesis and turnover of storage lipids, which are sequestered in lipid droplets (LDs).
Ben Leyland +2 more
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Porcine SCD1 Regulates Lipid Droplet Number via CLSTN3B in PK15 Cells
AnimalsFat deposition plays a key role in determining porcine meat quality traits, with lipid droplets serving as critical organelles for lipid storage in adipose tissue. Inhibiting lipid droplet biogenesis disrupts the lipid storage capacity of adipocytes. The
Wenzhe Bai +7 more
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