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Cell, 2009 Lipid droplets (LDs) are universal cellular organelles that specialize in the storage of neutral lipids, such as sterol esters and triacylglycerols (see Essay by Farese and Walther, this issue). As such, they provide the main cellular reservoir for lipids of energy storage and membrane synthesis, and they protect cells from the lipotoxic effects of ...
Krahmer, N. +3 more
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A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
Frontiers in Chemistry, 2021 Lipid droplets (LDs), an extremely important cellular organelle, are responsible for the storage of neutral lipids in multiple biological processes, which could be a potential target site for photodynamic therapy (PDT) of cancer.
Xiang Xia +9 more
doaj +1 more source
TIP47 Is Not a Component of Lipid Droplets [PDF]
Journal of Biological Chemistry, 2001 TIP47 functions in the delivery of mannose 6-phosphate receptors from endosomes to the trans-Golgi network both in vitro and in vivo. It binds directly and very specifically to the cytoplasmic domains of both the cation-independent and cation-dependent mannose 6-phosphate receptors.
Barbero, Pierre +3 more
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Bottom-up assembly of functional intracellular synthetic organelles by droplet-based microfluidics
, 2020 Bottom-up synthetic biology has directed most efforts toward the construction of artificial compartmentalized systems that recreate living cell functions in their mechanical, morphological, or metabolic characteristics.
Platzman, I. +3 more
core +1 more source
Interfacial Reactions of Ozone with Surfactant Protein B in a Model Lung Surfactant System [PDF]
, 2010 Oxidative stresses from irritants such as hydrogen peroxide and ozone (O_3) can cause dysfunction of the pulmonary surfactant (PS) layer in the human lung, resulting in chronic diseases of the respiratory tract.
Beauchamp, J. L. +9 more
core +2 more sources
The lipase cofactor CGI58 controls placental lipolysis
JCI Insight, 2023 In eutherians, the placenta plays a critical role in the uptake, storage, and metabolism of lipids. These processes govern the availability of fatty acids to the developing fetus, where inadequate supply has been associated with substandard fetal growth.
Jennifer Guerrero-Santoro +11 more
doaj +1 more source
Lipid droplets and polyunsaturated fatty acid trafficking: Balancing life and death
Frontiers in Cell and Developmental Biology, 2023 Lipid droplets are fat storage organelles ubiquitously distributed across the eukaryotic kingdom. They have a central role in regulating lipid metabolism and undergo a dynamic turnover of biogenesis and breakdown to meet cellular requirements for fatty ...
Mauro Danielli +3 more
doaj +1 more source
Lipid Droplets in Health and Disease [PDF]
Lipids in Health and Disease, 2017 Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals. They are composed of a hydrophobic neutral lipid core surrounding by a phospholipid monolayer membrane with various decorating ...
Gizem Onal +3 more
openaire +5 more sources
Lipid droplet detection by the cavity perturbation method [PDF]
, 2011 There are currently no point-of-care diagnosis strategies available to indicate the presence of neoplasmic growth. This research aims to develop a novel diagnostic strategy based on detecting TAG accumulation in cells.
A I Al-Shamma'a +7 more
core +1 more source
Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. [PDF]
PLoS ONE, 2015 Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins.
Joseph D Love +7 more
doaj +1 more source