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Lipid droplets at a glance [PDF]
Journal of Cell Science, 2009 Lipid droplets (LDs) are the major cellular organelles for the storage of neutral lipids. Excessive lipid storage in LDs is central to the pathogenesis of prevalent metabolic diseases, such as obesity, diabetes and atherosclerosis; LDs are, therefore, crucial in the development of these diseases.
Guo, Y. +3 more
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The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly.
PLoS Pathogens, 2020 Lipid droplets are essential cellular organelles for storage of fatty acids and triglycerides. The hepatitis C virus (HCV) translocates several of its proteins onto their surface and uses them for production of infectious progeny.
Gabrielle Vieyres +4 more
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PAT family proteins pervade lipid droplet cores
Journal of Lipid Research, 2005 The PAT family proteins, named after perilipin, adipophilin, and the tail-interacting protein of 47 kDa (TIP47), are implicated in intracellular lipid metabolism. They associate with lipid droplets, but how is completely unclear.
Horst Robenek +2 more
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Lipid droplet biogenesis [PDF]
Current Opinion in Cell Biology, 2014 Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane.
Wilfling, F. ; https://orcid.org/0000-0002-6559-7261 +3 more
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LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid β-oxidation of lipid droplets. [PDF]
PLoS ONE, 2012 Lipid storage droplet protein 5 (LSDP5) is a lipid droplet-associated protein of the PAT (perilipin, adipophilin, and TIP47) family that is expressed in the liver in a peroxisome proliferator-activated receptor alpha (PPARα)-dependent manner; however ...
Hang Li +9 more
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The Plant Cell, 2022 Abstract Membrane contact sites (MCSs) are interorganellar connections that allow for the direct exchange of molecules, such as lipids or Ca2+ between organelles, but can also serve to tether organelles at specific locations within cells.
Hannah Elisa Krawczyk +14 more
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Lipid Droplets in Cancer [PDF]
, 2020 Abstract Lipid droplets have a unique structure among organelles consisting of a dense hydrophobic core of neutral lipids surrounded by a single layer of phospholipids decorated with various proteins. Often labeled merely as passive fat storage repositories, they in fact have a remarkably dynamic life cycle.
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Lipid Droplets and Cellular Lipid Metabolism [PDF]
Annual Review of Biochemistry, 2012 Among organelles, lipid droplets (LDs) uniquely constitute a hydrophobic phase in the aqueous environment of the cytosol. Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism. In addition, LDs are implicated in a number of other cellular functions, ranging from protein storage ...
Tobias C, Walther, Robert V, Farese
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Cell, 2009 Lipid droplets (LDs) are universal cellular organelles that specialize in the storage of neutral lipids, such as sterol esters and triacylglycerols (see Essay by Farese and Walther, this issue). As such, they provide the main cellular reservoir for lipids of energy storage and membrane synthesis, and they protect cells from the lipotoxic effects of ...
Krahmer, N. +3 more
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TIP47 Is Not a Component of Lipid Droplets [PDF]
Journal of Biological Chemistry, 2001 TIP47 functions in the delivery of mannose 6-phosphate receptors from endosomes to the trans-Golgi network both in vitro and in vivo. It binds directly and very specifically to the cytoplasmic domains of both the cation-independent and cation-dependent mannose 6-phosphate receptors.
Barbero, Pierre +3 more
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