Results 11 to 20 of about 863,741 (256)

Lipid Droplets in Disease

Cells, 2019
Lipid droplets (LDs) are a crucial part of lipid storage; thus, they are important players in a variety of diseases that are affected by lipid imbalances such as obesity, fatty liver disease, type 2 diabetes, Alzheimer’s disease, cardiovascular ...
Paul Dalhaimer
doaj   +2 more sources

Retinyl esters form lipid droplets independently of triacylglycerol and seipin [PDF]

, 2021
Lipid droplets store neutral lipids, primarily triacylglycerol and steryl esters. Seipin plays a role in lipid droplet biogenesis and is thought to determine the site of lipid droplet biogenesis and the size of newly formed lipid droplets. Here we show a
Prieur, Xavier, Chorlay, Aymeric, Veterinaire biochemie, Toulmay, Alexandre, Lukmantara, Ivan E, Mari, Muriel C, Sub Biochemistry of Membranes begr1-6-12, dB&C FR-RMSC FR, Haaker, Maya W, Houweling, Martin, Yadav, Kamlesh K, Schneiter, Roger, Wubbolts, Richard W, Helms, J Bernd, Celbiologie, Molenaar, Martijn R, Thiam, Abdou Rachid, Prinz, William A, dB&C I&I, IOV CCB, Vaandrager, Arie Bas, Yang, Hongyuan, Wassenaar, Tsjerk A, Reggiori, Fulvio, Choudhary, Vineet, Caillon, Lucie, Dep Scheikunde, dB&C FR-RMSC RMSC   +27 more
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BODIPY-based Fluorescent Indicators for Lipid Droplets [PDF]

, 2023
Lipid droplets are essential for cellular lipid storage, playing critical roles in cellular lipid metabolism. Although lipid droplets have drawn intense research in recent years, much remains to be uncovered about the roles of this organelle in biology ...
Kai, Kikuchi, Elizabeth J, New, Nian Kee, Tan, Amandeep, Kaur, Jianping, Zhu   +4 more
core   +2 more sources

Microsomal Triglyceride Transfer Protein (MTP) Associates with Cytosolic Lipid Droplets in 3T3-L1 Adipocytes. [PDF]

PLoS ONE, 2015
Lipid droplets are intracellular energy storage organelles composed of a hydrophobic core of neutral lipid, surrounded by a monolayer of phospholipid and a diverse array of proteins.
Joseph D Love, Takashi Suzuki, Delia B Robinson, Carla M Harris, Joyce E Johnson, Peter J Mohler, W Gray Jerome, Larry L Swift   +7 more
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Lipid droplet analysis in caveolin-deficient adipocytes: alterations in surface phospholipid composition and maturation defects[S]

Journal of Lipid Research, 2010
Caveolins form plasmalemnal invaginated caveolae. They also locate around intracellular lipid droplets but their role in this location remains unclear. By studying primary adipocytes that highly express caveolin-1, we characterized the impact of caveolin-
Cédric M. Blouin, Soazig Le Lay, Anita Eberl, Harald C. Köfeler, Ida Chiara Guerrera, Christophe Klein, Xavier Le Liepvre, Françoise Lasnier, Olivier Bourron, Jean-François Gautier, Pascal Ferré, Eric Hajduch, Isabelle Dugail   +12 more
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Surface-associated lipid droplets: an intermediate site for lipid transport in human adipocytes?

Adipocyte, 2020
Adipose tissue plays a major role in regulating whole-body energy metabolism. While the biochemical processes regulating storage and release of excess energy are well known, the temporal organization of these events is much less defined.
Björn Morén, Claes Fryklund, Karin Stenkula   +2 more
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Role of endogenous lipid droplets in lipolysis in rat adipocytes.

Journal of Lipid Research, 1994
Sonication of rat fat cells caused an increase in lipolysis in the absence of lipolytic stimulants (basal lipolysis) and loss of epinephrine responsiveness.
H Okuda, C Morimoto, T Tsujita
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Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein

Journal of Lipid Research, 1997
The adipose differentiation-related protein (ADRP) was first characterized as a mRNA induced early during adipocyte differentiation (Jiang, H. P., and G. Serrero. 1992. Proc. Natl. Acad. Sci. USA. 89:7856-7860).
D L Brasaemle, T Barber, N E Wolins, G Serrero, E J Blanchette-Mackie, C Londos   +5 more
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15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism

Journal of Lipid Research, 2009
15(S)-lipoxygenase-1 (15-LO-1) was present in the whole-cell homogenate of an acute human monocytic leukemia cell line (THP-1). Additionally, 15-LO-1 was detected on neutral lipid droplets isolated from THP-1 foam cells.
Ginny L. Weibel, Michelle R. Joshi, Cong Wei, Sandra R. Bates, Ian A. Blair, George H. Rothblat   +5 more
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An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

eLife, 2021
Lipid droplets are lipid storage organelles found in nearly all cell types from adipocytes to cancer cells. Although increasingly implicated in disease, current methods to study lipid droplets in vertebrate models rely on static imaging or the use of ...
Dianne Lumaquin, Eleanor Johns, Emily Montal, Joshua M Weiss, David Ola, Abderhman Abuhashem, Richard M White   +6 more
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