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Lipid droplets and cellular lipid flux [PDF]
Nature Cell BiologyLipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review the current understanding of the mechanisms of lipid droplet biogenesis and turnover, the transfer of lipids and metabolites at membrane contact sites, and the role of ...
Alyssa J. Mathiowetz, James A. Olzmann
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Pathophysiology of Lipid Droplets in Neuroglia [PDF]
Antioxidants, 2021 In recent years, increasing evidence regarding the functional importance of lipid droplets (LDs), cytoplasmic storage organelles in the central nervous system (CNS), has emerged. Although not abundantly present in the CNS under normal conditions in adulthood, LDs accumulate in the CNS during development and aging, as well as in some neurologic ...
Tina Smolič, Robert Zorec, Nina Vardjan
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The life of lipid droplets [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2009 Lipid droplets are the least characterized of cellular organelles. Long considered simple lipid storage depots, these dynamic and remarkable organelles have recently been implicated in many biological processes, and we are only now beginning to gain insights into their fascinating lives in cells.
Walther, T., Farese, R.
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BODIPY-based Fluorescent Indicators for Lipid Droplets [PDF]
, 2023 Lipid droplets are essential for cellular lipid storage, playing critical roles in cellular lipid metabolism. Although lipid droplets have drawn intense research in recent years, much remains to be uncovered about the roles of this organelle in biology ...
Kai, Kikuchi +4 more
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Lipid droplets at a glance [PDF]
Journal of Cell Science, 2009 Lipid droplets (LDs) are the major cellular organelles for the storage of neutral lipids. Excessive lipid storage in LDs is central to the pathogenesis of prevalent metabolic diseases, such as obesity, diabetes and atherosclerosis; LDs are, therefore, crucial in the development of these diseases.
Guo, Y. +3 more
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Lipid droplet biogenesis [PDF]
Current Opinion in Cell Biology, 2014 Lipid droplets (LDs) are found in most cells, where they play central roles in energy and membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly understood process involving the formation of a monolayer bound organelle from a bilayer membrane.
Wilfling, F. ; https://orcid.org/0000-0002-6559-7261 +3 more
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The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective
Biomolecules, 2023 It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic alterations, and loss of proteostasis—exist that describe the cellular aging process.
Nikolaus Bresgen +4 more
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eLife, 2021 Cytoplasmic lipid droplets are highly dynamic storage organelles that are critical for cellular lipid homeostasis. While the molecular details of lipid droplet dynamics are a very active area of investigation, this work has been primarily performed in ...
Meredith H Wilson +2 more
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Journal of Lipid Research, 2005 Hydrolysis of intracellular cholesteryl esters (CEs) represents the first step in the removal of cholesterol from lipid-laden foam cells associated with atherosclerotic lesions.
Bin Zhao +4 more
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The Plant Cell, 2022 Abstract Membrane contact sites (MCSs) are interorganellar connections that allow for the direct exchange of molecules, such as lipids or Ca2+ between organelles, but can also serve to tether organelles at specific locations within cells.
Hannah Elisa Krawczyk +14 more
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