Results 1 to 10 of about 13,212 (232)

Perilipin overexpression in mice protects against diet-induced obesity [PDF]

Journal of Lipid Research, 2010
Perilipin A is the most abundant phosphoprotein on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Perilipin null mice exhibit diminished adipose tissue, elevated basal lipolysis, reduced catecholamine-stimulated lipolysis, and
Hideaki Miyoshi, Sandra C. Souza, Mikiko Endo, Takashi Sawada, James W. Perfield, II, Chikara Shimizu, Zlatina Stancheva, So Nagai, Katherine J. Strissel, Narihito Yoshioka, Martin S. Obin, Takao Koike, Andrew S. Greenberg   +12 more
doaj   +2 more sources

Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis. [PDF]

PLoS ONE, 2013
Lipolysis in adipocytes is regulated by phosphorylation of lipid droplet-associated proteins, including perilipin 1A and hormone-sensitive lipase (HSL).
Patrick M McDonough, Dominique Maciejewski-Lenoir, Sean M Hartig, Rita A Hanna, Ross Whittaker, Andrew Heisel, James B Nicoll, Benjamin M Buehrer, Kurt Christensen, Maureen G Mancini, Michael A Mancini, Dean P Edwards, Jeffrey H Price   +12 more
doaj   +2 more sources

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL

Cells, 2022
The single nucleotide polymorphism I148M of the lipase patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and
Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth, Beate Katharina Straub   +10 more
doaj   +2 more sources

The effect of educational and encouraging interventions on anthropometric characteristics and perilipin-1 levels: TABASSOM Study [PDF]

ARYA Atherosclerosis, 2021
BACKGROUND: Perilipin protein located in lipid droplets is involved in formation and storage of lipid in adipocytes; thus, it is considered as one of the obesity biomarkers.
Maryam Maghroun, Noushin Mohammadifard, Firoozeh Sajjadi, Narges Jafaridinani, Simin Karimi, Katayoun Rabiei, Soraya Massoudi, Nizal Sarrafzadegan   +7 more
doaj   +1 more source

Impact of blood perilipin A levels on obesity and metabolic health

BMC Research Notes, 2022
Objective Perilipin A is a common protein that coats lipid surfaces preventing them from being exposed to oxidative damage. Researchers have found little consistency in the relationship between perilipin A levels in the blood and body fat. This study was
Emmanuel K. Ofori, Bright Selorm Letsu, Seth K. Amponsah, John Ahenkorah, Sandra Crabbe, Genevieve Kwao-Zigah, Sylvester Y. Oppong, Patrick Diaba-Nuhoho, Seth D. Amanquah   +8 more
doaj   +1 more source

Autoantibodies Against Perilipin 1 as a Cause of Acquired Generalized Lipodystrophy

Frontiers in Immunology, 2018
Acquired generalized lipodystrophy (AGL) is a rare condition characterized by an altered distribution of adipose tissue and predisposition to develop hepatic steatosis and fibrosis, diabetes, and hypertriglyceridemia.
Fernando Corvillo, Fernando Corvillo, Verónica Aparicio, Alberto López-Lera, Alberto López-Lera, Sofía Garrido, Sofía Garrido, David Araújo-Vilar, María P. de Miguel, Margarita López-Trascasa, Margarita López-Trascasa, Margarita López-Trascasa   +11 more
doaj   +1 more source

Fatty acids regulate perilipin5 in muscle by activating PPARδ[S]

Journal of Lipid Research, 2013
The surface of lipid droplets (LDs) in various cell types is coated with perilipin proteins encoded by the Plin genes. Perilipins regulate LD metabolism by selectively recruiting lipases and other proteins to LDs.
Christian Bindesb⊘ll, Ole Berg, Borghild Arntsen, Hilde I. Nebb, Knut Tomas Dalen   +4 more
doaj   +1 more source

A Perilipin Affects Lipid Droplet Homeostasis and Aerial Hyphal Growth, but Has Only Small Effects on Virulence in the Insect Pathogenic Fungus Beauveria bassiana

Journal of Fungi, 2022
Lipid assimilation, storage, and turnover impact growth, development, and virulence in many microbial pathogens including fungi. Perilipins are proteins associated with lipid droplets (LDs) that mediate their assembly and turnover. Here, we characterized
Xiaoyun Wang, Yu Liu, Nemat O. Keyhani, Shengan Zhu, Jing Wang, Junyao Wang, Dan Jin, Yanhua Fan   +7 more
doaj   +1 more source

Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery

Natural Product Communications, 2012
The results obtained from our previous study showed that the addition of a lychee fruit-derived low molecular form of polyphenol, Oligonol, provoked higher levels of lipolytic activity via the degradation of perilipin 1 in primary rat adipocytes.
Junetsu Ogasawara, Kentaro Kitadate, Hiroshi Nishioka, Hajime Fujii, Takuya Sakurai, Takako Kizaki, Tetsuya Izawa, Hitoshi Ishida, Hideki Ohno   +8 more
doaj   +1 more source

TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ transcriptional activitys⃞

Journal of Lipid Research, 2008
In the course of an effort to identify the regulators for peroxisome proliferator-activated receptor γ (PPARγ)-dependent perilipin gene expression, we found that tribbles homolog 3 (TRB3), containing a single kinase domain without enzymatic activity ...
Yu Takahashi, Nobumichi Ohoka, Hidetoshi Hayashi, Ryuichiro Sato   +3 more
doaj   +1 more source