Results 31 to 40 of about 13,212 (232)

Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Journal of Lipid Research, 2007
The majority of eukaryotic cells synthesize neutral lipids and package them into cytosolic lipid droplets. In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major energy storage depot for the body, whereas cholesteryl ester-rich
Dawn L. Brasaemle
doaj   +1 more source

Perilipin1 Expression as a Prognostic Factor in Patients with Squamous Cell Carcinoma of the Lung

Diagnostics, 2023
Perilipin (PLIN) is a major structural protein located on the surface of lipid droplets. PLIN plays an important role in human metabolism and is associated with metabolic diseases, such as obesity, diabetes, hypertension, and endocrine disorders.
Min Hye Kim, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Hyo Jung An, Ji Min Na, Wook Jae Jung, Dae Hyun Song   +8 more
doaj   +1 more source

A Flexible Network of Lipid Droplet Associated Proteins Support Embryonic Integrity of C. elegans

Frontiers in Cell and Developmental Biology, 2022
In addition to coordinating the storage and mobilization of neutral fat, lipid droplets (LDs) are conserved organelles that can accommodate additional cargos in order to support animal development.
Zhe Cao, Chun Wing Fung, Ho Yi Mak
doaj   +1 more source

Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice[S]

Journal of Lipid Research, 2010
Lipid droplet proteins (LDPs) coat the surface of triglyceride-rich lipid droplets and regulate their formation and lipolysis. We profiled hepatic LDP expression in fatty liver dystrophic (fld) mice, a unique model of neonatal hepatic steatosis that ...
Angela M. Hall, Elizabeth M. Brunt, Zhouji Chen, Navin Viswakarma, Janardan K. Reddy, Nathan E. Wolins, Brian N. Finck   +6 more
doaj   +1 more source

Integrated Action of Autophagy and Adipose Tissue Triglyceride Lipase Ameliorates Diet-Induced Hepatic Steatosis in Liver-Specific PLIN2 Knockout Mice

Cells, 2021
An imbalance in the storage and breakdown of hepatic lipid droplet (LD) triglyceride (TAG) leads to hepatic steatosis, a defining feature of non-alcoholic fatty liver disease (NAFLD).
John D. Griffin, Eloy Bejarano, Xiang-Dong Wang, Andrew S. Greenberg   +3 more
doaj   +1 more source

Perilipin 5: putting the brakes on lipolysis [PDF]

Journal of Lipid Research, 2013
Lipid droplets serve a vital function in many types of cells. In most cells of the body, cholesterol esters stored in lipid droplets are thought to serve as a source of cholesterol for membrane synthesis and repair when dietary cholesterol is scarce (1).
openaire   +2 more sources

BODIPY-C₁₂ incorporates into Perilipin-2 and Perilipin-3 labeled cytotrophoblast lipid droplets.

, 2016
Cytotrophoblast plated for 4hr onto glass coverslips were incubated with 2μM BODIPY-C12 for 30 minutes and fixed as described in the methods section. Cells were immunolabeled with Perilipin-2 or Perilipin-3. Nuclei are labeled using Hoechst dye.
Samantha Louey (2607346), Kent Thornburg (2607349), Oleg Varlamov (2607352), Kevin Kolahi (2636749)   +3 more
core   +1 more source

PLINs-mediated organelle interactions: a key of exercise-mediated improvement of skeletal muscle lipid metabolism disorders

Frontiers in Endocrinology
Perilipins are essential structural proteins localized on the surface of lipid droplets, with perilipin 2, 3, and 5 exhibiting specific expression in skeletal muscle.
Zhiyuan Liu, Yungang Zhao
doaj   +1 more source

Mitochondrial and cellular mechanisms for managing lipid excess

Frontiers in Physiology, 2014
Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with ...
Miguel A Aon, Niraj eBhatt, Sonia C Cortassa   +2 more
doaj   +1 more source

Differential Splicing of Perilipin 5

The FASEB Journal, 2019
Included among the most common diseases in the U.S., are metabolic diseases such as type II diabetes mellitus and nonalcoholic fatty liver disease. Understanding these diseases requires an understanding of neutral lipid storage and metabolism. Perilipins are a family of five conserved proteins that function in the regulation of neutral lipid metabolism.
Spencer P Jordan, John T Tansey
openaire   +1 more source