Results 51 to 60 of about 13,212 (232)
Porcine perilipin (PLIN) gene: Structure, polymorphism and association study in Large White pigs
Czech Journal of Animal Science, 2009 Perilipin, encoded by the PLIN gene, is a lipid droplet-associated phosphoprotein that functions as a key regulator of triacylglycerol storage and hydrolysis in adipocytes.
Z. Vykoukalová, A. Knoll, S. Čepica
doaj +1 more source
Homology Modeling of Perilipin 5
The FASEB Journal, 2012 The perilipin family of lipid droplet proteins consists of five members. The most recently discovered protein, perilipin 5, also referred to as OXPAT, is primarily found in oxidative tissue and is believed to participate in lipid storage and trafficking within cells. While the protein structures of other proteins in the family, such as TIP47, have been
Zach Niday, John Tansey
openaire +1 more source
Surface-associated lipid droplets: an intermediate site for lipid transport in human adipocytes?
Adipocyte, 2020 Adipose tissue plays a major role in regulating whole-body energy metabolism. While the biochemical processes regulating storage and release of excess energy are well known, the temporal organization of these events is much less defined.
Björn Morén +2 more
doaj +1 more source
Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source
Site-Directed Mutagenesis of the Hydrophobic Cleft of Perilipin 5 [PDF]
, 2020 Type II diabetes mellitus, non-alcoholic fatty liver disease, obesity, and heart disease are all affected by atypical lipid storage. Lipid storage droplets are found in most somatic cells, however problems can arise.
Cool, Lillian
core
Inducible nitric oxide synthase modulates lipolysis in adipocytes
Journal of Lipid Research, 2005 The role of inducible nitric oxide synthase (iNOS) in the modulation of adipocyte lipolysis was investigated. Treatment of white and brown adipose cell lines and mouse adipose explants with a mixture of tumor necrosis factor-α, interferon-γ, and ...
Patrice Penfornis, André Marette
doaj +1 more source
Advanced Science, EarlyView.POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu +12 more
wiley +1 more source
Journal of Lipid Research, 2005 Lipiddroplet-associated proteins play an important role in adipocyte triglyceride (TG) metabolism. Here, weshow that trans-10,cis-12 conjugated linoleic acid (CLA), but notcis-9,trans-11 CLA, increased lipolysis and altered human adipocyte lipid ...
Soonkyu Chung +3 more
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UCHL1 Regulates Lipid and Perilipin 2 Level in Skeletal Muscle
Frontiers in Physiology, 2022 Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that was originally found in neurons. We found that UCHL1 is highly expressed in slow oxidative skeletal muscles, but its functions remain to be fully understood.
Ryan Antony +5 more
doaj +1 more source
Advanced Science, EarlyView.During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen +10 more
wiley +1 more source