Results 71 to 80 of about 13,212 (232)
Determination of antibody specificity for perilipin 1A PKA-site 5, and PKA-site 6.
, 2013 Hela cells were transfected separately with plasmids encoding wild-type (GFP, green) or mutant (mCherry, red) perilipin 1A (PLIN1) plasmids. Oleic acid was added for 24 h, followed by 7 min treatment with 24 µM forskolin plus 125 µM IBMX and the cells ...
Patrick M. McDonough (284824) +12 more
core +1 more source
eLife, 2017 Perilipin (PLIN) proteins constitute an ancient family important in lipid droplet (LD) formation and triglyceride metabolism. We identified an additional PLIN clade (plin6) that is unique to teleosts and can be traced to the two whole genome duplications
James G Granneman +6 more
doaj +1 more source
Normalized neutral lipid quantitation by flow cytometry
Journal of Lipid Research, 2018 Interest in measuring tissue lipids has increased as the link between fat-laden tissues and metabolic disease has become obvious; however, linking disease to a specific cell type within a tissue has been hampered by methodological limitations.
Nathan E. Wolins +3 more
doaj +1 more source
The Perilipin Family of Proteins: Structural and Bioinformatic Analysis
, 2021 With an increase in lipid-related diseases in countries all over the world, it has become crucial to study these diseases at the molecular level.
Stahl, Morgan A
core
Journal of Lipid Research, 2005 Hydrolysis of intracellular cholesteryl esters (CEs) represents the first step in the removal of cholesterol from lipid-laden foam cells associated with atherosclerotic lesions.
Bin Zhao +4 more
doaj +1 more source
Identification of Perilipin-2 as a lipid droplet protein regulated in oocytes during maturation
, 2010 Lipid droplet proteins regulate the storage and utilisation of intracellular lipids. Evidence is emerging that oocyte lipid utilisation impacts embryo development, but lipid droplet proteins have not been studied in oocytes.
Kylie R. Dunning +15 more
core +1 more source
Intracellular Transportation of Perilipin 5 [PDF]
, 2023 Lipid metabolism is the basis of many metabolic diseases that are effecting the US. A rise in the body’s free fatty acids can occur in diseases like diabetes mellitus and metabolic syndrome, which results in oxidative stress in the mitochondria.
Shields, Mara
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Activation of AMP-Activated Protein Kinase Attenuates Tumor Necrosis Factor-α-Induced Lipolysis via Protection of Perilipin in 3T3-L1 Adipocytes [PDF]
Endocrinology and Metabolism, 2014 BackgroundTumor necrosis factor (TNF)-α and AMP-activated protein kinase (AMPK) are known to stimulate and repress lipolysis in adipocytes, respectively; however, the mechanisms regulating these processes have not been completely elucidated.MethodsThe ...
Seok-Woo Hong +7 more
doaj +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Inhibition of Nuclear Transport of Perilipin 5
, 2022 Obesity, type II diabetes mellitus, and non-alcoholic fatty liver disease are all conditions related to aberrant lipid storage in humans. Nearly all cells have the capacity to store neutral lipids in lipid storage droplets, organelles that regulate the ...
Lewis, Hope
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