Results 91 to 100 of about 13,212 (232)

Immunocytochemical Studies on Lipid Droplet-Surface Proteins in Adrenal Cells

, 2009
Perilipin and ADRP, located on the surface of intracellular lipid droplets, are proposed to be involved in adipocyte lipid metabolism. The aim of the present study was to investigate the effect of PKA and PKC activities on the distribution of perilipin ...
FONG, TSORNG-HARN;WANG, SEU-MEI, 馮琮涵;王淑美   +1 more
core  

Hormonal control of reversible translocation of perilipin B to the plasma membrane in primary human adipocytes

, 2006
In adipocytes, perilipin coats and protects the central lipid droplet, which stores triacylglycerol. Alternative mRNA splicing gives rise to perilipin A and B.
Strålfors, Peter,, Vener, Alexander V,, Aboulaich, Nabila,   +2 more
core   +1 more source

Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes

Adipocyte lipolysis was compared with hormone-sensitive lipase (HSL)/perilipin subcellular distribution and perilipin phosphorylation using Western blot analysis.
Yeaman SJ; Clifford GM; Londos C; Kraemer FB; Vernon RG
core   +4 more sources

Perilipin2 depletion causes lipid droplet enlargement in the ovarian corpus luteum in mice

The Journal of Reproduction and Development
Lipid droplets (LDs) are endoplasmic reticulum-derived organelles that store neutral lipids (mostly triglycerides and cholesterol esters) within a phospholipid monolayer and appear in most eukaryotic cells.
Megumi IBAYASHI, Takayuki TATSUMI, Satoshi TSUKAMOTO   +2 more
doaj   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

The Characterization of a Putative Perilipin-5 Splice Variant

, 2016
Lipid droplets, or LDs, are very important and dynamic organelles in cells. LDs are stores of fat for use in metabolism, membrane construction, and signaling.
Hardy, Cara C
core  

The transport of protein aggregates to the vacuole suggests a role for lipid droplets in waste disposal in Saccharomyces cerevisiae

The FEBS Journal, EarlyView.
Lipid droplets (LD) act as cellular ‘garbage trucks’ that transport cytosolic protein aggregates to the vacuole for degradation in yeast. Protein aggregates are docked to lipid droplets in a triacylglycerol‐dependent manner, transported through the cytoplasm, and transferred to the insoluble protein deposit (IPOD) at the vacuole.
Christoph Reiter, Patrick Ebner, Elli Leona Kronsteiner, Sophia Moustakakis, Markus Wiederstein, Astrid Obermayer, Ronald Thomas Huber, Christian Schloegelhofer, Florian Wieser, Jon Cedrick Richter, Isabelle Guirsch, Patrick Rockenfeller, Jana Vojtová, Tomáš Groušl, Thomas Klaus Felder, Mark Rinnerthaler   +15 more
wiley   +1 more source

Characterization of a Perilipin‐5 Splice Variant

The FASEB Journal, 2011
Perilipin‐5, the newest member of the perilipin family of lipid droplet proteins, has been found to be expressed in oxidative tissues, specifically heart, brown adipose tissue, and fasted liver. This work seeks to characterize a novel splice variant for perilipin‐5 we have termed Perilipin‐5B.
Daniel M DuBreuil, John T Tansey
openaire   +1 more source

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Perilipins: Current perspectives on the role in cardiovascular diseases

iScience
The perilipin (PLIN) protein family serves as key structural and regulatory proteins on the surface of lipid droplets (LDs), which in turn ensures the storage and mobilization of fatty acids (FAs) in cardiac cells, thereby promoting FAs oxidation and playing a central role in the regulation of cardiomyocytes.
Zhang, Yuxi, Zhan, Junbiao, Qiu, Zhen, Tian, Hao, Yang, Huilan, Lu, Kunzhi, Xia, Zhongyuan   +6 more
openaire   +2 more sources