Results 81 to 90 of about 13,212 (232)
Phytotherapy Research, EarlyView.Liquiritigenin promotes expression of CGI‐58 and enhances lipolysis by down‐regulating expression of PLIN2, thereby facilitating the catabolism of larger‐sized lipid droplets and producing smaller‐sized lipid droplets, resulting in enhanced activity of lipophagy and ameliorated hepatic steatosis. ABSTRACT Metabolic‐associated fatty liver disease (MAFLD)
Zhuoya Xu +7 more
wiley +1 more source
Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine
Phytotherapy Research, EarlyView.By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao +11 more
wiley +1 more source
Characterization of the cytosolic pool of perilipin 5
The FASEB Journal, 2013 The PAT family of lipid storage droplet (LD) associated proteins consists of five members, each an established regulator of neutral lipid metabolism. The most recently discovered family member, perilipin 5, has been shown to localize to two distinct intracellular pools: the lipid storage droplet and a cytosolic fraction, the nature of which is less ...
James A Brackbill +3 more
openaire +1 more source
, 2014 Protein expression of perilipin, ActRIIB and myostatin in a range of equine tissues was assessed by Western blot with total AKT used as a loading control.
Caroline McG. Argo (457164) +5 more
core +1 more source
Phosphorylated Perilipin Abundances Associated with Energy Mobilization in Lactating Dairy Cows [PDF]
, 2009 Perilipin, adipose triglyceride lipase (ATGL) and comparative gene identity-58 (CGI-58) are proteins recently associated with energy mobilization from adipose tissue of rodents and humans.
Spurlock, Diane, Elkins, Dawn
core +1 more source
Journal of Lipid Research, 2007 A lipid droplet (LD)-associated protein, perilipin, is a critical regulator of lipolysis in adipocytes. We previously showed that Comparative Gene Identification-58 (CGI-58), a product of the causal gene of Chanarin-Dorfman syndrome, interacts with ...
Yamaguchi Tomohiro +8 more
doaj +1 more source
Phytotherapy Research, EarlyView.Magnoflorine ameliorates metabolic dysfunction‐associated steatohepatitis by promoting AMPKα‐mediated lipophagy and fatty acid oxidation. ABSTRACT Emerging as a significant clinical burden, metabolic dysfunction‐associated steatohepatitis (MASH) continues to challenge global healthcare systems due to limited effective interventions.
Zhengjie Lu +6 more
wiley +1 more source
Interactions of Perilipin 5 with Cytoskeletal Elements
The FASEB Journal, 2019 Cardiovascular diseases, obesity, and diabetes are disease that are affecting the American population at alarming rates. Central to these diseases is lipid metabolism and lipid storage. Perilipin 5 is a protein found on the surface of lipid droplets within cells, but has also been found within the cytoplasm, mitochondria, and nucleus, and is implicated
Rachel L Austin, John T Tansey
openaire +1 more source
The Many Faces of Amphipathic Helices
Biomolecules, 2018 Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their structure and by the segregation of hydrophobic and polar residues between two faces of the helix.
Manuel Giménez-Andrés +2 more
doaj +1 more source
PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes
British Journal of Pharmacology, EarlyView.Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier +9 more
wiley +1 more source