Results 41 to 50 of about 13,212 (232)

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

Journal of Lipid Research, 2010
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage ...
Alan R. Kimmel, Dawn L. Brasaemle, Monica McAndrews-Hill, Carole Sztalryd, Constantine Londos   +4 more
doaj   +1 more source

Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis

Journal of Lipid Research, 2014
Long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous studies reveal significant associations between promoter single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 and T2DM, as ...
Chang-Hui Tsao, Ming-Yuh Shiau, Pei-Hua Chuang, Yih-Hsin Chang, Jaulang Hwang   +4 more
doaj   +1 more source

Perilipin Isoforms and PGC-1α Are Regulated Differentially in Rat Heart during Pregnancy-Induced Physiological Cardiac Hypertrophy

Medicina, 2022
Background and Objectives: Perilipins 1–5 (PLIN) are lipid droplet-associated proteins that participate in regulating lipid storage and metabolism, and the PLIN5 isoform is known to form a nuclear complex with peroxisome proliferator-activated receptor ...
Jesús A. Rosas-Rodríguez, Adolfo Virgen-Ortíz, Enrico A. Ruiz, Rudy M. Ortiz, José G. Soñanez-Organis   +4 more
doaj   +1 more source

Interaction of Perilipin 5 with Mitochondria

The FASEB Journal, 2019
Problems with lipid metabolism can lead to array of diseases such as fatty liver disease, obesity, and diabetes. Nearly one‐third of the world's population is obese or overweight, and struggle with these diseases. Cellular lipids are found in lipid storage droplets.
Claire I Todd, John T Tansey
openaire   +1 more source

Perilipins: a diversity of intracellular lipid droplet proteins [PDF]

Lipids in Health and Disease, 2017
Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs are not stable lipid-depots, they are active sites of neutral lipid metabolism, and comprise neutral lipid or cholesterol cores surrounded by phospholipid monolayers containing specialized ...
Hiroyuki Itabe, Tomohiro Yamaguchi, Satomi Nimura, Naoko Sasabe   +3 more
openaire   +3 more sources

Perilipin-1 in hemodialyzed patients: association with history of coronary heart disease and lipid profile

, 2012
Perilipin-1 surrounds lipid droplets in both adipocytes and in atheroma plaque foam cells and controls access of lipases to the lipid core. In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and atherosclerosis are common. Thirty-six
Stefanidis, Ioannis, Pissas, G., Galaktidou, G., Antoniadi, Georgia, Arampatzis, Spyridon, Antoniadi, G., Pissas, Georgios, Arampatzis, S., Stefanidis, I., Sparopoulou, T., Eleftheriadis, T., Liakopoulos, Vassilios, Sparopoulou, Theodora, Liakopoulos, V., Eleftheriadis, Theodoros, Galaktidou, Grammati   +15 more
core   +1 more source

Lipid body formation during maturation of human mast cells

Journal of Lipid Research, 2011
Lipid droplets, also called lipid bodies (LB) in inflammatory cells, are important cytoplasmic organelles. However, little is known about the molecular characteristics and functions of LBs in human mast cells (MC).
Andrea Dichlberger, Stefanie Schlager, Jani Lappalainen, Reijo Käkelä, Katarina Hattula, Sarah J. Butcher, Wolfgang J. Schneider, Petri T. Kovanen   +7 more
doaj   +1 more source

Confocal laser scan microscopy (CLSM) analysis of Perilipin in adipocytes.

, 2013
CLSM was used to validate and localize perilipin protein in human adipocytes as shown in figure 3. Fat organelles ( =  lipid droplets) were stained with FITC (green color), indicated by green arrow, and Perilipin was visualized with Texas red (red color)
Marcel de Vries (354275), Kees Meijer (354274), Han van der Want (354281), Bart-Jan Kroesen (64351), Martijn Dijkstra (354279), Desirée Weening (354278), Roelof Jan van der Leij (354280), Marcel Bruinenberg (354277), Niels Kloosterhuis (191336), Saad Al-Lahham (354276), Roel Vonk (354282), Farhad Rezaee (35414)   +11 more
core   +1 more source

Ginsenoside Rb1 ameliorates liver fat accumulation by upregulating perilipin expression in adipose tissue of db/db obese mice

Journal of Ginseng Research, 2015
Background: Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts antidiabetic effects. We tested whether the insulin-sensitizing and antidiabetic effects of G-Rb1 results from a reduction in ectopic ...
Xizhong Yu, Lifang Ye, Hao Zhang, Juan Zhao, Guoqiang Wang, Chao Guo, Wenbin Shang   +6 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source