Results 21 to 30 of about 13,212 (232)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Immunohistochemical staining for adipophilin, perilipin and TIP47 [PDF]

Journal of Clinical Pathology, 2006
Background: The presence of lipid in the cell cytoplasm is useful for supporting the diagnosis of sebaceous gland carcinoma (SGC). Currently this requires histochemical stains that are carried out on frozen sections of unprocessed tissue.
K, Muthusamy, G, Halbert, F, Roberts
openaire   +2 more sources

Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I [PDF]

, 2022
OBJECTIVE: Heart attack is one of the most common causes of sudden death in adults. Therefore, early detection of heart attack and investigation of potential new biomarkers are of great importance.
Ethem, İbrahim, Hacıoğlu, Ceyhan
core   +1 more source

Perilipin-1 immunostaining improves semi-automated digital quantitation of bone marrow adipocytes in histological bone sections

, 2023
Bone marrow adipocytes (BMAds) are not just passive fillers inside the bone marrow compartment but respond to various metabolic changes. Assessment of those responses requires evaluation of the number of BMAds and their morphology for which laborious and
Kaisa K. Ivaska (11323935), Niki Jalava (14188433), Nicko Widjaja (14188436), Yimeng Chen (6634163)   +3 more
core   +1 more source

Perilipin-Induktion und Dynamik der Expression Lipidtropfen-assoziierter Proteine in menschlicher Leberparenchymverfettung und in Steatose-Zellkulturmodellen [PDF]

, 2013
Die hepatozelluläre Steatose ist die häufigste Lebererkrankung in westlichen Industrieländern und geht mit einer erhöhten Inzidenz für Steatohepatitis, Leberzirrhose und hepatozelluläre Karzinome einher.
Pawella, Lena Maria
core   +1 more source

The differential expression of perilipin-2 in hepatoblastoma and its association with prognosis [PDF]

, 2021
Perilipin-2, a lipid droplet (LD) coating protein, has been found to be involved in cancer progression. However, its role in hepatoblastoma (HB) is undefined. We collected 87 HB samples and the corresponding clinical data. Immunohistochemistry (IHC)
Yamada, Sohsuke, Ura, Hiroki, Azukisawa, Sadafumi, Niida, Yo, Zheng, Jianbo, Guo, Xin, Itoh, Tohru   +6 more
core   +1 more source

Cytoplasmic lipid droplet accumulation in developing mammary epithelial cells: roles of adipophilin and lipid metabolism

Journal of Lipid Research, 2007
PAT proteins (perilipin, adipophilin, and TIP47) are hypothesized to be critical regulators of lipid accumulation in eukaryotic cells. We investigated the developmental relationships between the expression of these proteins and cytoplasmic lipid droplet (
Tanya D. Russell, Carol A. Palmer, David J. Orlicky, Andreas Fischer, Michael C. Rudolph, Margaret C. Neville, James L. McManaman   +6 more
doaj   +1 more source

Study of the impact of perilipin polymorphisms in a French population [PDF]

Journal of Negative Results in BioMedicine, 2006
Perilipins are proteins localized at the surface of the lipid droplet in adipocytes, steroid-producing cells and ruptured atherosclerotic plaques playing a role in the regulation of triglyceride deposition and mobilization. We investigated whether perilipin gene polymorphisms were associated with obesity, type 2 diabetes, and their related variables ...
Meirhaeghe, Aline, Thomas, Séverine, Ancot, Frédéric, Cottel, Dominique, Arveiler, Dominique, Ferrières, Jean, Amouyel, Philippe   +6 more
openaire   +3 more sources

Exposure to tumescent solution significantly increases phosphorylation of perilipin in adipocytes [PDF]

, 2017
BACKGROUND: Lidocaine and epinephrine could potentially decrease adipocyte viability, but these effects have not been substantiated. The phosphorylation status of perilipin in adipocytes may be predictive of cell viability. Perilipin coats lipid droplets
Keskin, İlknur, Eren, Hilal, Keskin, Mustafa, Sütçü, Mustafa   +3 more
core   +1 more source

Hydrophobic sequences target and anchor perilipin A to lipid droplets

Journal of Lipid Research, 2004
Perilipins regulate triacylglycerol storage and hydrolysis in adipocytes. The central 25% of the perilipin A sequence, including three hydrophobic sequences (H1, H2, and H3) and an acidic region, targets and anchors perilipins to lipid droplets. Thus, we
Vidya Subramanian, Anne Garcia, Anna Sekowski, Dawn L. Brasaemle   +3 more
doaj   +1 more source