Results 11 to 20 of about 13,212 (232)

Imaging cytoplasmic lipid droplets in vivo with fluorescent perilipin 2 and perilipin 3 knock-in zebrafish

eLife, 2021
Cytoplasmic lipid droplets are highly dynamic storage organelles that are critical for cellular lipid homeostasis. While the molecular details of lipid droplet dynamics are a very active area of investigation, this work has been primarily performed in ...
Meredith H Wilson, Stephen C Ekker, Steven A Farber   +2 more
doaj   +4 more sources

Probing the Function of Perilipin 5b [PDF]

The FASEB Journal, 2020
Many modern health issues arise from aberrant lipid metabolism, among these are type II diabetes and non‐alcoholic fatty liver disease. One commonality these diseases share is neutral lipid metabolism and storage. Regulation of neutral lipid metabolism is of vital importance in the body, and among the proteins responsible for such regulation are the ...
Rebekah C. Dalton, John T. Tansey
openaire   +2 more sources

Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and obese [PDF]

Lipids in Health and Disease, 2009
Background Mainly dependent on hormone-sensitive lipase, lipolysis is differently impaired between fat depots in human obesity. Perilipin A expression is a critical element in adipocyte lipolysis.
Beylot Michel, Frering Vincent, Pinteur Claudie, Ray Hind, Large Valérie   +4 more
doaj   +2 more sources

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue [PDF]

Journal of Lipid Research, 2007
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis).
Sandra C. Souza, Marcelo A. Christoffolete, Miriam O. Ribeiro, Hideaki Miyoshi, Katherine J. Strissel, Zlatina S. Stancheva, Nicole H. Rogers, Tara M. D'Eon, James W. Perfield, II, Hitomi Imachi, Martin S. Obin, Antonio C. Bianco, Andrew S. Greenberg   +12 more
doaj   +2 more sources

Characterization of the Perilipin 5 C‐Terminus [PDF]

The FASEB Journal, 2019
Many countries around the globe have been plagued with a recent epidemic in lipid‐associated diseases. These diseases include obesity, diabetes, and non‐alcoholic fatty liver disease among many others. The United States itself has fallen heavily victim to these ailments, placing first in worldwide rankings for obese persons and within the top fiftieth ...
Tim D Clinton, Derek T Wei, John T Tansey   +2 more
openaire   +2 more sources

Layer-Specific Dermal and Subcutaneous Delivery via Modular LNP-Hydrogel-Integrated Threaded Microneedles. [PDF]

Adv Sci (Weinh)
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Xie F, Zhang Y, Ling S, Huang Y, Wei Y, Fu R, He J, Liu B, Zhou L, Huo K, Wang Y, Li Q, Du Y, Cui W, Xie Y.   +14 more
europepmc   +2 more sources

Roles of Perilipins in Diseases and Cancers [PDF]

Current Genomics, 2018
Perilipins, an ancient family of lipid droplet-associated proteins, are embedded in a phospho-lipid monolayer of intracellular lipid droplets. The core of lipid droplets is composed of neutral fat, which mainly includes triglyceride and cholesterol ester.
Zhang, Pengpeng, Meng, Lian, Song, Lingxie, Du, Juan, Du, Shutong, Cui, Wenwen, Liu, Chunxia, Li, Feng   +7 more
openaire   +2 more sources

Update on perilipin polymorphisms and obesity [PDF]

Nutrition Reviews, 2012
Perilipin proteins were discovered in the adipocyte, where they regulate lipid storage and lipolysis. Animal knockout models provided initial evidence of the critical role of perilipin 1, the most abundant of the adipocyte proteins, in energy and glucose metabolism.
Caren E, Smith, José M, Ordovás
openaire   +2 more sources

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source