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Lipid Droplets in Health and Disease [PDF]
Lipids in Health and Disease, 2017 Lipids are essential building blocks synthesized by complex molecular pathways and deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found in almost all organisms, from bacteria to mammals. They are composed of a hydrophobic neutral lipid core surrounding by a phospholipid monolayer membrane with various decorating ...
Gizem Onal +3 more
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Lipid metabolism and HCV infection [PDF]
, 2010 Chronic infection by hepatitis C virus (HCV) can lead to severe liver disease and is a global healthcare problem. The liver is highly metabolically active and one of its key functions is to control the balance of lipid throughout the body.
Boulant, Steeve +11 more
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Role of endogenous lipid droplets in lipolysis in rat adipocytes.
Journal of Lipid Research, 1994 Sonication of rat fat cells caused an increase in lipolysis in the absence of lipolytic stimulants (basal lipolysis) and loss of epinephrine responsiveness.
H Okuda, C Morimoto, T Tsujita
doaj +1 more source
Surface-associated lipid droplets: an intermediate site for lipid transport in human adipocytes?
Adipocyte, 2020 Adipose tissue plays a major role in regulating whole-body energy metabolism. While the biochemical processes regulating storage and release of excess energy are well known, the temporal organization of these events is much less defined.
Björn Morén +2 more
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Journal of Lipid Research, 1997 The adipose differentiation-related protein (ADRP) was first characterized as a mRNA induced early during adipocyte differentiation (Jiang, H. P., and G. Serrero. 1992. Proc. Natl. Acad. Sci. USA. 89:7856-7860).
D L Brasaemle +5 more
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The Gregarious Lipid Droplet [PDF]
Journal of Biological Chemistry, 2008 Cytoplasmic lipid droplets were considered until recently to be in the same category as glycogen granules, simple storage sites for energy, waxing and waning as metabolic energy needs dictated, but otherwise inert particles. It has become clear, however, that droplets are much more than isolated storage depots in the cell and that they can skate around
openaire +2 more sources
Journal of Lipid Research, 2009 15(S)-lipoxygenase-1 (15-LO-1) was present in the whole-cell homogenate of an acute human monocytic leukemia cell line (THP-1). Additionally, 15-LO-1 was detected on neutral lipid droplets isolated from THP-1 foam cells.
Ginny L. Weibel +5 more
doaj +1 more source
An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish
eLife, 2021 Lipid droplets are lipid storage organelles found in nearly all cell types from adipocytes to cancer cells. Although increasingly implicated in disease, current methods to study lipid droplets in vertebrate models rely on static imaging or the use of ...
Dianne Lumaquin +6 more
doaj +1 more source
Identification of the lipid droplet targeting domain of the Cidea protein[S]
Journal of Lipid Research, 2010 Cidea, the cell death-inducing DNA fragmentation factor-α-like effector (CIDE) domain-containing protein, is targeted to lipid droplets in mouse adipocytes, where it inhibits triglyceride hydrolysis and promotes lipid storage.
Jennifer L. Christianson +4 more
doaj +1 more source
Scientific Reports, 2022 We report the utilization of Third-Harmonic Generation microscopy for label-free live cell imaging of lipid droplets in the hypha of filamentous fungus Phycomyces blakesleeanus.
Tanja Pajić +6 more
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