Results 101 to 110 of about 847,311 (317)

Lipid Acyl Chain Remodeling in Yeast

, 2016
Membrane lipid homeostasis is maintained by de novo synthesis, intracellular transport, remodeling, and degradation of lipid molecules. Glycerophospholipids, the most abundant structural component of eukaryotic membranes, are subject to acyl chain ...
De Smet, Cedric H, de Kroon, Anton I P M, Sub Membrane Biochemistry & Biophysics, Sub Membrane Enzymology begr. 01-06-12, Membrane Biochemistry and Biophysics, Renne, Mike F, Bao, Xue   +6 more
core   +1 more source

Caveolae biogenesis and lipid sorting at the plasma membrane

, 2022
The plasma membrane of many cell types, in particular, endothelia, smooth muscle cells, and adipocytes, contains numerous small invaginations termed caveolae.
Hubert, Madlen,, Liu, Kang Cheng,, Lundmark, Richard,, Larsson, Elin,   +3 more
core   +1 more source

A lipidomics roadmap: from basic research to societal challenges

Nature Communications
Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems.
Maria Fedorova, Anne K. Bendt, Justine Bertrand-Michel, Oliver Fiehn, Joanna Godzien, Laura Goracci, Florian Gruber, Xue Li Guan, Xianlin Han, Michal Holčapek, Julia Kuligowski, Peter J. Meikle, Palina Nepachalovich, Valerie B. O’Donnell, Matej Orešič, Sider Penkov, Snježana Petrović, Anton Potapov, Patricia Prabutzki, Laura Righetti, Tatjana Ruskovska, Andrej Shevchenko, Kai Simons, Corinne M. Spickett, Olga Vvedenskaya, Jennifer Watts, Markus R. Wenk, Michael Witting, Yu Xia, Baoru Yang, Maria Rosário Domingues   +30 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Effect of Cholesterol and Ibuprofen on DMPC-β-Aescin Bicelles: A Temperature-Dependent Wide-Angle X-ray Scattering Study

Crystals, 2020
β -aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries.
Ramsia Geisler, Sylvain Prévost, Rajeev Dattani, Thomas Hellweg   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Shaped Apertures in Photoresist Films Enhance the Lifetime and Mechanical Stability of Suspended Lipid Bilayers

, 2014
Planar lipid bilayers suspended in apertures provide a controlled environment for ion channel studies. However, short lifetimes and poor mechanical stability of suspended bilayers limit the experimental throughput of bilayer electrophysiology experiments.
Kalsi, S., Powl, A.M., Wallace, Bonnie A., Wallace, B.A., Morgan, Hywel, Kalsi, Sumit, Morgan, H., de Planque, M.R.R., Powl, Andrew M., de Planque, Maurits R.R.   +9 more
core   +1 more source

Impact of lipid asymmetry on membrane biophysical properties: Insights from molecular dynamics simulations

Quantitative Biology
Asymmetry between outer and inner leaflets of cell membrane, such as variations in phospholipid composition, cholesterol (CHOL) distribution, stress levels, and ion environments, could significantly influence the biophysical properties of membranes ...
Yong Zhang, Jizhong Lou
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The ELBA force field for coarse-grain modeling of lipid membranes

, 2011
A new coarse-grain model for molecular dynamics simulation of lipid membranes is presented. Following a simple and conventional approach, lipid molecules are modeled by spherical sites, each representing a group of several atoms.
Orsi Mario, Essex Jonathan W., Essex, JW, Essex, Jonathan W., Orsi, M, Jonathan W Essex, Jonathan W. Essex, Mario Orsi, Orsi, Mario   +8 more
core   +1 more source