Results 91 to 100 of about 847,311 (317)

Aggregation modulators interfere with membrane interactions of beta2-microglobulin fibrils. [PDF]

, 2013
Amyloid fibril accumulation is a pathological hallmark of several devastating disorders, including Alzheimer's disease, prion diseases, type II diabetes, and others.
Xue, Wei-Feng, Xue, W-F, Sheynis, Tania, Sheynis, T, Radford, Sheena E., Tipping, KW, Radford, SE, Hellewell, AL, Jelinek, Raz, Friediger, Anat, Friediger, A, Tipping, Kevin W., Hellewell, Andrew L., Hewitt, Eric W., Tipping, Kevin W, Hewitt, EW, Jelinek, R   +16 more
core   +1 more source

Unlocking the mysteries of VLDL: exploring its production, intracellular trafficking, and metabolism as therapeutic targets

Lipids in Health and Disease
Reducing circulating lipid levels is the centerpiece of strategies for preventing and treating atherosclerotic cardiovascular disease (ASCVD). Despite many available lipid-lowering medications, a substantial residual cardiovascular risk remains.
Jingfei Chen, Zhenfei Fang, Qin Luo, Xiao Wang, Mohamad Warda, Avash Das, Federico Oldoni, Fei Luo   +7 more
doaj   +1 more source

Global and local effects in lipid-mediated interactions between peripheral and integral membrane proteins

Frontiers in Molecular Biosciences
Amphitropic proteins (APs) are a subfamily of water-soluble peripherally membrane-bound proteins that interact directly with the lipid membrane rather than with intrinsic membrane proteins and are therefore strongly influenced by membrane properties ...
Tatiana K. Rostovtseva, David P. Hoogerheide, William A. Milhizer, Sergey M. Bezrukov   +3 more
doaj   +1 more source

Lipid Organization of the Plasma Membrane

Journal of the American Chemical Society, 2014
The detailed organization of cellular membranes remains rather elusive. Based on large-scale molecular dynamics simulations, we provide a high-resolution view of the lipid organization of a plasma membrane at an unprecedented level of complexity. Our plasma membrane model consists of 63 different lipid species, combining 14 types of headgroups and 11 ...
Ingólfsson, Helgi I, Melo, Manuel N, van Eerden, Floris J, Arnarez, Clément, Lopez, Cesar A, Wassenaar, Tsjerk A, Periole, Xavier, de Vries, Alex H, Tieleman, D Peter, Marrink, Siewert J   +9 more
openaire   +2 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Lipid Conversion by Cell-Free Synthesized Phospholipid Methyltransferase Opi3 in Defined Nanodisc Membranes Supports an in Trans Mechanism [PDF]

, 2018
Biomembranes composed of lipids and proteins play central roles in physiological processes, and the precise balance between different lipid species is crucial for maintaining membrane function.
Henrich, Erik, Pawlik, Grzegorz, Morgner, Nina, Dötsch, Volker, De Kroon, Anton I., Peetz, Oliver, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics, Bernhard, Frank, Löhr, Frank   +9 more
core   +1 more source

Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer

Nature Communications
A spontaneously occurring temperature increase in solid tumors has been reported sporadically, but is largely overlooked in terms of cancer biology. Here we show that temperature is increased in tumors of patients with pancreatic ductal adenocarcinoma ...
Vincent de Laat, Halit Topal, Xander Spotbeen, Ali Talebi, Jonas Dehairs, Jakub Idkowiak, Frank Vanderhoydonc, Tessa Ostyn, Peihua Zhao, Maarten Jacquemyn, Michele Wölk, Anna Sablina, Koen Augustyns, Tom Vanden Berghe, Tania Roskams, Dirk Daelemans, Maria Fedorova, Baki Topal, Johannes V. Swinnen   +18 more
doaj   +1 more source

Membrane-Mediated Lateral Interactions Regulate the Lifetime of Gramicidin Channels

Membranes, 2020
The lipid matrix of cellular membranes is an elastic liquid crystalline medium. Its deformations regulate the functionality and interactions of membrane proteins,f membrane-bound peptides, lipid and protein-lipid domains.
Oleg V. Kondrashov, Timur R. Galimzyanov, Rodion J. Molotkovsky, Oleg V. Batishchev, Sergey A. Akimov   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Manipulation of lipid rafts in neuronal cells

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core