Results 71 to 80 of about 775,217 (268)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Lipids in membrane protein structures

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2004
This review describes the recent knowledge about tightly bound lipids in membrane protein structures and deduces general principles of the binding interactions. Bound lipids are grouped in annular, nonannular, and integral protein lipids. The importance of lipid binding for vertical positioning and tight integration of proteins in the membrane, for ...
Palsdottir, Hildur, Hunte, Carola
openaire   +4 more sources

Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer

Nature Communications
A spontaneously occurring temperature increase in solid tumors has been reported sporadically, but is largely overlooked in terms of cancer biology. Here we show that temperature is increased in tumors of patients with pancreatic ductal adenocarcinoma ...
Vincent de Laat, Halit Topal, Xander Spotbeen, Ali Talebi, Jonas Dehairs, Jakub Idkowiak, Frank Vanderhoydonc, Tessa Ostyn, Peihua Zhao, Maarten Jacquemyn, Michele Wölk, Anna Sablina, Koen Augustyns, Tom Vanden Berghe, Tania Roskams, Dirk Daelemans, Maria Fedorova, Baki Topal, Johannes V. Swinnen   +18 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

A lipidomics roadmap: from basic research to societal challenges

Nature Communications
Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems.
Maria Fedorova, Anne K. Bendt, Justine Bertrand-Michel, Oliver Fiehn, Joanna Godzien, Laura Goracci, Florian Gruber, Xue Li Guan, Xianlin Han, Michal Holčapek, Julia Kuligowski, Peter J. Meikle, Palina Nepachalovich, Valerie B. O’Donnell, Matej Orešič, Sider Penkov, Snježana Petrović, Anton Potapov, Patricia Prabutzki, Laura Righetti, Tatjana Ruskovska, Andrej Shevchenko, Kai Simons, Corinne M. Spickett, Olga Vvedenskaya, Jennifer Watts, Markus R. Wenk, Michael Witting, Yu Xia, Baoru Yang, Maria Rosário Domingues   +30 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Lipid Organization of the Plasma Membrane

Journal of the American Chemical Society, 2014
The detailed organization of cellular membranes remains rather elusive. Based on large-scale molecular dynamics simulations, we provide a high-resolution view of the lipid organization of a plasma membrane at an unprecedented level of complexity. Our plasma membrane model consists of 63 different lipid species, combining 14 types of headgroups and 11 ...
Ingólfsson, Helgi I, Melo, Manuel N, van Eerden, Floris J, Arnarez, Clément, Lopez, Cesar A, Wassenaar, Tsjerk A, Periole, Xavier, de Vries, Alex H, Tieleman, D Peter, Marrink, Siewert J   +9 more
openaire   +2 more sources

Enhanced Microscopic Dynamics of a Liver Lipid Membrane in the Presence of an Ionic Liquid

Frontiers in Chemistry, 2020
Ionic liquids (ILs) are an important class of emerging compounds, owing to their widespread industrial applications in high-performance lubricants for food and cellulose processing, despite their toxicity to living organisms.
Veerendra K. Sharma, Veerendra K. Sharma, Sajal K. Ghosh, Victoria García Sakai, R. Mukhopadhyay, R. Mukhopadhyay   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Impact of lipid asymmetry on membrane biophysical properties: Insights from molecular dynamics simulations

Quantitative Biology
Asymmetry between outer and inner leaflets of cell membrane, such as variations in phospholipid composition, cholesterol (CHOL) distribution, stress levels, and ion environments, could significantly influence the biophysical properties of membranes ...
Yong Zhang, Jizhong Lou
doaj   +1 more source