Results 111 to 120 of about 1,385,198 (299)

Interaction of Hematoporphyrin with Lipid Membranes

The Journal of Physical Chemistry B, 2012
Natural or synthetic porphyrins are being used as photosensitizers in photodiagnosis (PD) and photodynamic therapy (PDT) of malignancies and some other diseases. Understanding the interactions between porphyrins and cell membranes is therefore important to rationalize the uptake of photosensitizers and their passive transport through cell membranes. In
M. Stepniewski, M. Kepczynski, D. Jamroz, M. Nowakowska, S. Rissanen, I. Vattulainen, and T. Rog   +6 more
openaire   +5 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Deciphering the Assembly of Enveloped Viruses Using Model Lipid Membranes

, 2022
The cell plasma membrane is mainly composed of phospholipids, cholesterol and embedded proteins, presenting a complex interface with the environment.
Brémaud, Erwan, Muriaux, Delphine, Favard, Cyril, Erwan Brémaud, Delphine Muriaux, Cyril Favard   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The effect of modulating membrane lipid composition on the thermal sensitivity of tumour cells in culture [PDF]

, 1989
The plasma membrane, which separates intracellular contents from extra cellular milieu, consists of a lipid bilayer comprising mainly phospholipids and cholesterol together with various functional proteins, which control the interaction of the cell with ...
Kingston, Catharine Alison
core  

Lipid‐protein interactions in membranes [PDF]

FEBS Letters, 1990
The interactions of lipids with integral and peripheral proteins can be studied in reconstituted and natural membranes using spin label electron spin resonance (ESR) spectroscopy. The ESR spectra reveal a reduction in mobility of the spin‐labelled lipid chains on binding of peripheral proteins to negatively‐charged lipid bilayers.
openaire   +3 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Micromachined glass apertures for artificial lipid bilayer formation in a microfluidic system

, 2007
The use of spark assisted chemical engraving (SACE) to produce glass apertures that are suitable for the formation of artificial bilayer lipid membranes is described.
Abu-Hantash, M., Zagnoni, M., Sandison, M.E., Morgan, H.   +3 more
core  

Repurposing a Lipid Droplet‐Associated Algal Protein as a Biosensor for Phosphatidic Acid

Advanced Sensor Research
Phosphatidic acid (PA) is an essential signaling lipid in eukaryotic cells. Despite its importance, biosensors recognizing PA‐rich membranes are in short supply, partly because there is no known consensus motif for detecting PA. Here, we demonstrate that
Bilge Ercan, Nian Kee Tan, Julia Lin, Jingyao You, Stephen M. Butler, Katrina A. Jolliffe   +5 more
doaj   +1 more source