Results 1 to 10 of about 847,311 (317)
An Overview of Lutein in the Lipid Membrane. [PDF]
Int J Mol Sci, 2023 Lutein, zeaxanthin, and meso-zeaxanthin (a steroisomer of zeaxanthin) are macular pigments. They modify the physical properties of the lipid bilayers in a manner similar to cholesterol. It is not clear if these pigments are directly present in the lipid phase of the membranes, or if they form complexes with specific membrane proteins that retain them ...
Widomska J +3 more
europepmc +4 more sources
Atomistic-Level Structural Insight into Vespa Venom (Ves a 1) and Lipid Membrane Through the View of Molecular Dynamics Simulation [PDF]
ToxinsThis study used all-atom molecular dynamics simulations to investigate the structural dynamics of Ves a 1, a phospholipase from Vespa affinis venom, and its interactions within a lipid membrane environment, both alone and in the presence of the inhibitor
Nawanwat Chainuwong Pattaranggoon +5 more
doaj +2 more sources
Lipid and Lipidation in Membrane Fusion
The Journal of Membrane Biology, 2022 Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion proteins that catalyze and regulate the fusion. Interestingly, various types of fusion proteins are present in nature and they possess diverse mechanisms of action.
Avijit Sardar +4 more
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Cells, 2023 Astrocytes are critical players in brain health and disease. Brain pathologies and lesions are usually accompanied by astroglial alterations known as reactive astrogliosis.
Shah Alam +6 more
doaj +1 more source
Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis
Molecular Oncology, 2022 Sphingosine‐1‐phosphate (S1P), a bioactive signaling lipid, is involved in several vital processes, including cellular proliferation, survival and migration, as well as neovascularization and inflammation.
Sumaiya Y. Afsar +3 more
doaj +1 more source
Molecular Oncology, 2021 Cancer development is a multistep process in which cells must overcome a series of obstacles before they can become fully developed tumors. First, cells must develop the ability to proliferate unchecked.
Antonia Piazzesi +2 more
doaj +1 more source
Cells, 2020 We have shown that sphingosine 1-phosphate (S1P) generated by sphingosine kinase 2 (SK2) is toxic in neurons lacking S1P-lyase (SGPL1), the enzyme that catalyzes its irreversible cleavage.
Shah Alam +4 more
doaj +1 more source
Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism
Nature Communications, 2023 Phospholipase D3 (PLD3) polymorphisms are linked to late-onset Alzheimer’s disease (LOAD). Being a lysosomal 5’-3’ exonuclease, its neuronal substrates remained unknown as well as how a defective lysosomal nucleotide catabolism connects to AD ...
Zoë P. Van Acker +11 more
doaj +1 more source
Nature Communications, 2022 Oxidized lipids are prominent bioactive agents, and yet their molecular repertoire remains largely unknown. Here, the authors apply bioinformatics and LC-MS/MS to uncover the diversity and specificity of modified lipids in human blood plasma of lean and ...
Angela Criscuolo +9 more
doaj +1 more source
Lipid membranes with an edge [PDF]
Physical Review E, 2002 Consider a lipid membrane with a free exposed edge. The energy describing this membrane is quadratic in the extrinsic curvature of its geometry; that describing the edge is proportional to its length. In this note we determine the boundary conditions satisfied by the equilibria of the membrane on this edge, exploiting variational principles.
Capovilla, R. +2 more
openaire +3 more sources