Results 1 to 10 of about 1,216,026 (349)

Differential Metabolism of Medium-Chain Fatty Acids in Differentiated Human-Induced Pluripotent Stem Cell-Derived Astrocytes

Frontiers in Physiology, 2019
Medium-chain triglyceride (MCT) ketogenic diets increase ketone bodies, which are believed to act as alternative energy substrates in the injured brain. Octanoic (C8:0) and decanoic (C10:0) acids, which produce ketone bodies through β-oxidation, are used
Sarah Sonnay, Anirikh Chakrabarti, Jonathan Thevenet, Andreas Wiederkehr, Nicolas Christinat, Mojgan Masoodi, Mojgan Masoodi   +6 more
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Exploring Valine Metabolism in Astrocytic and Liver Cells: Lesson from Clinical Observation in TBI Patients for Nutritional Intervention

Biomedicines, 2020
The utilization of alternative energy substrates to glucose could be beneficial in traumatic brain injury (TBI). Recent clinical data obtained in TBI patients reported valine, β-hydroxyisobutyrate (ibHB) and 2-ketoisovaleric acid (2-KIV) as three of the ...
Sarah Sonnay, Nicolas Christinat, Jonathan Thevenet, Andreas Wiederkehr, Anirikh Chakrabarti, Mojgan Masoodi   +5 more
doaj   +1 more source

Ameliorative Effects of Monoammonium-Glycyrrhizinate on Liver Lipid Metabolism and Antioxidant Capacity in Laying Hens [PDF]

, 2020
Mengke Wang, Shucheng Huang, Cai Zhang, Haizhou Gong, Shunan Cuan, Shuaishuai Wang, Qi Shao, Wenhao Xu, Sudan Meng, Pengfei Li, Yuqin Wang, Zijun Yang   +11 more
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The luminal domain region of Seipin/Fld1 is dispensable for establishing functional ER sites for lipid droplet biogenesis

Nature Communications
Lipid droplet (LD) biogenesis occurs in the endoplasmic reticulum (ER), the mechanisms of which is not completely known. Seipin (Fld1 in yeast) is a crucial ER membrane protein that defines LD biogenesis sites.
Amit Khatri, Ritika Chaudhary, R. Mankamna Kumari, Vineet Choudhary   +3 more
doaj   +1 more source

Beta-Arrestin 1 Mediates Liver Thyrotropin Regulation of Cholesterol Conversion Metabolism via the Akt-Dependent Pathway

International Journal of Endocrinology, 2018
After activation, G protein-coupled receptors (GPCRs) are desensitized by β-arrestins (ARRBs). Moreover, ARRBs can initiate a second wave of signaling independent of G proteins. Thyroid-stimulating hormone receptor (TSHR) is one of the GPCR members.
Shaona Niu, Hui Li, Wenbin Chen, Jiajun Zhao, Ling Gao, Tao Bo   +5 more
doaj   +1 more source

Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat

Journal of Lipid Research, 1999
Early events in the metabolic processing of dietary triacylglycerol may have an important impact on subsequent development of risk factors for coronary heart disease.
Lucinda K.M. Summers, Barbara A. Fielding, Sara L. Herd, Vera Ilic, Mo L. Clark, Paul T. Quinlan, Keith N. Frayn   +6 more
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Alterations in Biomarkers Related to Glycemia, Lipid Metabolism, and Inflammation up to 20 Years Before Diagnosis of Type 1 Diabetes in Adults: Findings From the AMORIS Cohort [PDF]

, 2021
Katharina Herzog, Tomas Andersson, Valdemar Grill, Niklas Hammar, Håkan Malmström, Mats Talbäck, Göran Walldius, Sofia Carlsson   +7 more
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Effects of gender and menopausal status on plasma lipoprotein subspecies and particle sizes

Journal of Lipid Research, 1996
The risk of coronary heart disease (CHD) is lower in women than in men, but increases in women after menopause. Some of the gender, age, and menopausal-related differences in CHD risk may relate to differences in lipoprotein subspecies.
Z Li, J R McNamara, J C Fruchart, G Luc, J M Bard, J M Ordovas, P W Wilson, E J Schaefer   +7 more
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Deletion of Macrophage Vitamin D Receptor Promotes Insulin Resistance and Monocyte Cholesterol Transport to Accelerate Atherosclerosis in Mice

Cell Reports, 2015
Intense effort has been devoted to understanding predisposition to chronic systemic inflammation because it contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) in mice (KODMAC) is sufficient to ...
Jisu Oh, Amy E. Riek, Isra Darwech, Katsuhiko Funai, JianSu Shao, Kathleen Chin, Oscar L. Sierra, Geert Carmeliet, Richard E. Ostlund Jr., Carlos Bernal-Mizrachi   +9 more
doaj   +1 more source

Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B

Journal of Lipid Research, 1996
In order to investigate causes of variability in low density lipoprotein (LDL) particle size, we have assessed LDL composition in plasma from 66 subjects, each with a single LDL band, by 2-16% gradient gel electrophoresis, with a total of eight discrete ...
J R McNamara, D M Small, Z Li, E J Schaefer   +3 more
doaj   +1 more source