Results 1 to 10 of about 3,232,425 (402)

Overexpression of SCAP inhibits autophagy and promotes lipid accumulation in vascular smooth muscle cells

Di-san junyi daxue xuebao, 2022
Objective To determine the effect of sterol regulatory element binding proteins cleavage activating protein (SCAP) on foam cell formation in vascular smooth muscle cells (VSMCs). Methods LV-SCAP were constructed with LV-SCAP, and LV-Control group served
RAO Yuhan, LI Danyang, HOU Xiaoli, YAO Yincheng, SU Yu   +4 more
doaj   +1 more source

Lipid metabolism and rheumatoid arthritis

Frontiers in Immunology, 2023
As a chronic progressive autoimmune disease, rheumatoid arthritis (RA) is characterized by mainly damaging the synovium of peripheral joints and causing joint destruction and early disability.
Qian Lei, Jie Yang, Li Li, Ning Zhao, Cheng Lu, A. Lu, Xiaojuan He   +6 more
semanticscholar   +1 more source

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

The FEBS Journal, 2022
Alzheimer’s disease (AD) is an age‐associated neurodegenerative disorder with multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of disease‐modifying therapeutics.
F. Yin
semanticscholar   +1 more source

Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways

Clinical science, 2022
The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin resistance.
O. Badmus, S. Hillhouse, C. D. Anderson, T. Hinds, D. Stec   +4 more
semanticscholar   +1 more source

First Case Report of Arrhythmogenic Right Ventricular Cardiomyopathy Showing Refractory Ventricular Tachycardia Induced by Thyroid Storm due to Graves’ Disease

Case Reports in Endocrinology, 2022
A 48-year-old man who was diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) due to a plakophilin 2 gene mutation developed acute both-sided heart failure with rapid atrial fibrillation and was hospitalized.
Masaki Matsubara, Tomohiro Tanaka, Akinori Wakamiya, Tamiko Tamanaha, Hisashi Makino, Tomonori Tanei, Takeshi Aiba, Kengo Kusano, Kiminori Hosoda   +8 more
doaj   +1 more source

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Molecular Neurodegeneration, 2022
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery.
Ruirui Li, Qi Qin, Hanchen Yang, Ying-Ying Wang, Yingxin Mi, Yunsi Yin, Meng Wang, Chaonan Yu, Yi Tang   +8 more
semanticscholar   +1 more source

Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases

Cell & Bioscience, 2022
The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years.
Danying Yang, Xifeng Wang, Lieliang Zhang, Yang Fang, Qingcui Zheng, Xing Liu, Wen Yu, Shoulin Chen, Jun Ying, Fuzhou Hua   +9 more
semanticscholar   +1 more source

Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study.

Journal of Lipid Research, 1994
Plasma low density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, and apolipoprotein (apo) B, the major protein constituent of LDL, were measured in 1,533 men (mean age 49 +/- 10 years) and 1,597 women (mean age 49 +/- 10 ...
E J Schaefer, S Lamon-Fava, S D Cohn, M M Schaefer, J M Ordovas, W P Castelli, P W Wilson   +6 more
doaj   +1 more source

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Oxidative Medicine and Cellular Longevity, 2014
Lipid peroxidation can be described generally as a process under which oxidants such as free radicals attack lipids containing carbon-carbon double bond(s), especially polyunsaturated fatty acids (PUFAs).
A. Ayala, Mario F. Muñoz, S. Argüelles
semanticscholar   +1 more source

Factors associated with low and elevated plasma high density lipoprotein cholesterol and apolipoprotein A-I levels in the Framingham Offspring Study.

Journal of Lipid Research, 1994
A decreased high density lipoprotein (HDL) cholesterol level (< 35 mg/dl) has been shown to be a significant independent risk factor for coronary heart disease (CHD).
E J Schaefer, S Lamon-Fava, J M Ordovas, S D Cohn, M M Schaefer, W P Castelli, P W Wilson   +6 more
doaj   +1 more source