Results 71 to 80 of about 19,908 (200)
Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
wiley +1 more source
ABSTRACT Clarifying the molecular mechanisms underlying salt tolerance in high‐performing sorghum‐sudangrass hybrids can aid the identification of salt tolerance genes. Here, the previously screened salt‐tolerant sorghum‐sudangrass hybrid variety MN9 and the salt‐sensitive variety MN4 were grown in sand‐filled pots.
Yue Shi +4 more
wiley +1 more source
ABSTRACT Objective To determine associations between gestational diabetes mellitus (GDM) and body mass index (BMI) change between consecutive pregnancies, and hospital length of stay (LOS) and hospital costs. Design Retrospective cohort study. Setting Two maternity hospitals, New South Wales, Australia.
Rashidul Alam Mahumud +4 more
wiley +1 more source
Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells
Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son +7 more
wiley +1 more source
ABSTRACT Background Prenatal exposure to bisphenol A (BPA), an endocrine‐disrupting chemical, may influence childhood obesity. Evidence on sex‐specific effects remains inconsistent. Methods We analysed 528 mother–child pairs from a Korean birth cohort. Maternal urinary BPA concentrations were measured during mid‐pregnancy.
Youn‐Hee Lim +7 more
wiley +1 more source
ABSTRACT This prospective observational study investigated whether systolic blood pressure variability (SBPV) during the transitional care period predicts long‐term outcomes after coronary artery bypass grafting (CABG). We enrolled 120 consecutive patients undergoing isolated CABG between 2020 and 2024 in a structured Transitional Care Service System ...
Pujuan Liu +7 more
wiley +1 more source
ABSTRACT Oil sorghum (OS) has been developed by engineering grain (TX430) and sweet (Ramada) genetic backgrounds to accumulate triacylglycerols (TAG) in vegetative tissues as an energy‐dense feedstock for sustainable aviation fuel (SAF) and other biofuels. This study evaluated two TX430 OS lines (TxHO‐2, TxHO‐3) and two Ramada OS lines (RmHO‐1, RmHO‐2)
Yunzhu Chen +13 more
wiley +1 more source
Integrated transcriptomic, single‐cell, pseudotime, cell–cell communication, human tissue, and in vivo analyses define a dynamic four‐gene axis across the MASLD continuum. Progressive CYP2C19 downregulation and AKR1B10, COL1A2, and SPP1 upregulation link metabolic dysfunction to disease progression, while AKR1B10 knockdown or CYP2C19 overexpression ...
Kejun Liu +5 more
wiley +1 more source
Synaptic metabolism and brain circuitries in inborn errors of metabolism
À. García-Cazorla +2 more
semanticscholar +1 more source
Do inborn errors of metabolism confer or impede the risk of diabetes?
V. Peters, J. Vockley
semanticscholar +1 more source

