Results 181 to 190 of about 133,206 (305)

In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy

Advanced Materials, EarlyView.
We have developed an intracellular crystalline polymerization strategy involving acid‐catalyzed imine condensation to synthesize COFs in lysosomes. The generation of COFs in lysosomes damages their integrity, activates iron species, and induces immunogenic ferroptosis, thereby enhancing antitumor immunotherapy.
Qun Guan, Le‐Le Zhou, Zhiqing Yang, Yan‐An Li, Leyong Wang, Ruibing Wang   +5 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Advancing Cancer Immunotherapy Using Lipid Nanoparticle-Based Approaches. [PDF]

Int J Nanomedicine
Prazeres PHDM, Costa da Silva GH, Azevedo GV, Alves da Silva NJ, Carvalho Costa PA, Da Silva WN, Lobo AO, Guimaraes PPG.   +7 more
europepmc   +1 more source

Emergent Motility of Self‐Organized Particle‐Giant Unilamellar Vesicle Assembly

Advanced Materials, EarlyView.
Giant unilamellar vesicles (GUVs), when combined with silica particles under alternating electric fields, spontaneously self‐assemble into motile structures. Asymmetric particle decoration induces fluid flows that propel the assemblies, enabling persistent motion and reversible control.
Selcan Karaz, Gaurav Gardi, Mertcan Han, Saadet Fatma Baltaci, Mukrime Birgul Akolpoglu, Metin Sitti   +5 more
wiley   +1 more source

Lipid nanoparticle-delivered intrabodies for inhibiting necroptosis and pyroptosis. [PDF]

Biochem J
Deepagan VG, Ma X, Bazregari F, Pang J, Schaefer J, Hildebrand JM, Dempsey RK, Doerflinger M, Baldwin CA, Schmidt FI, Murphy JM, Salvamoser R, Vince JE.   +12 more
europepmc   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

mRNA-lipid nanoparticle vaccines provide protection against lethal Nipah virus infection. [PDF]

NPJ Vaccines
Sun T, Yao Y, Tian C, Peng Y, Liu Y, Gao G, Li Z, Liu H, Han J, Chen M, Xiao S, Yuan Z, Shan C, Liu J, Chen H.   +14 more
europepmc   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Development of mRNA-lipid nanoparticle intrabodies against rickettsial infection. [PDF]

J Biomed Sci
Yan Q, Duan N, Lin M, Zhang W, Denton S, Zhong Y, Dong Y, Rikihisa Y.   +7 more
europepmc   +1 more source

High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting

Advanced Materials, EarlyView.
A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang, Xuehao Tian, Kuei Chen, Yang Wu, ChenCheng Xue, Yingjie Quek, Jessalyn Low, Arun Kumar, Andy Tay   +8 more
wiley   +1 more source