Results 191 to 200 of about 133,206 (305)

Lipid Nanoparticle Fas Gene Therapy Suppresses Autoimmune Lymphoproliferative Syndrome in Mice. [PDF]

Blood Immunol Cell Ther
Poschel DB, Tiamiyu Z, Redd P, Merting A, Savage N, Liu K.   +5 more
europepmc   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

A binary self-amplifying expression platform enabling lipid nanoparticle-free vaccines and nanomedicines. [PDF]

Nat Commun
Jefferies WA, Choi KB, Ribeca P, Kari S, Young JA, Hui E, Qi SY, Garrovillas E, Fan J, Cho BMY, Housh P, Welch T, Saranchova I, Pfeifer CG.   +13 more
europepmc   +1 more source

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

Enhanced Delivery of Lipid Nanoparticle-Based Immunotherapy by Modulating the Tumor Tissue Stiffness Using Ultrasound-Activated Nanobubbles. [PDF]

ACS Nano
Bhalotia A, Hutchinson DW, Kosmides T, Nittayacharn P, Mehta M, Iyer A, Cheplyansky A, Takizawa KH, Nidhiry A, Dever AM, Cousens KA, Hwang IM, Ramamurthy G, Exner AA, Karathanasis E.   +14 more
europepmc   +1 more source

Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities

Advanced Materials, EarlyView.
As healthcare moves toward decentralization, ultrasound technologies are evolving from strictly imaging tools in clinical settings into versatile diagnostic and therapeutic platforms, with growing roles addressing women's health needs. This review highlights how ultrasound's underlying physical mechanisms can be harnessed to reduce disparities in women'
Sarah B. Ornellas, Bilal Kizilaslan, Aastha Shah, Jason F. Hou, Yoonsoo Shin, Alejandra Hernandez Moyers, Claudia Lozano, Canan Dagdeviren   +7 more
wiley   +1 more source

Unique Aerofoil-Structured Microfluidics for High Throughput Lipid Nanoparticle Formulation Screening and Scale-up. [PDF]

Adv Sci (Weinh)
Liu D, Yu M, Zhang Y, Mathew A, Guan T, Yao L, Wang X, Wang W, Zhang N.   +8 more
europepmc   +1 more source

Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice [PDF]

, 2018
Akk, Antonina, Bacon, John, Hou, Kirk K, Miller, Mark J, Palekar, Rohun U, Pan, Hua, Pham, Christine T.N, Schlesinger, Paul H, Springer, Luke E, Wickline, Samuel A, Yan, Huimin, Yang, Lihua   +11 more
core   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source

Effects of Serum Incubation on Lipid Nanoparticle PEG Shedding, mRNA Retention, and Membrane Interactions. [PDF]

ACS Appl Mater Interfaces
Niederkofler S, Parkkila P, Aliakbarinodehi N, Sasanian N, Emilsson G, Ulkoski D, Ferreira CJO, Galenkamp NS, Silva BFB, Lundberg D, Jing Y, Lindfors L, Agnarsson B, Höök F.   +13 more
europepmc   +1 more source