Results 301 to 310 of about 2,353,041 (346)
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Lipid Packing in Lipid-Wrapped Nanoparticles
The Journal of Physical Chemistry B, 2018Equilibrium simulations of lipid-wrapped nanoparticles (LNP) were performed using a hybrid molecular dynamics/Monte Carlo (MD/MC) approach. The radius, R, of a spherical nanoparticle (NP) core was adjusted with MC moves while a surrounding lipid bilayer was treated with MD.
David Stelter, Tom Keyes
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2020
Recent advances in the development of nanocarriers have started a new era in Formulation Science. Among various nanoparticles, solid lipid nanoparticles (SLNs) offer an attractive carrier system to conventional colloidal carriers, such as emulsions, microemulsions, self micro-emulsifying drug delivery system, micellar systems, liposomes, polymeric ...
Akhlesh Kumar Jain, Suresh Thareja
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Recent advances in the development of nanocarriers have started a new era in Formulation Science. Among various nanoparticles, solid lipid nanoparticles (SLNs) offer an attractive carrier system to conventional colloidal carriers, such as emulsions, microemulsions, self micro-emulsifying drug delivery system, micellar systems, liposomes, polymeric ...
Akhlesh Kumar Jain, Suresh Thareja
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Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR–Cas9 ribonucleoprotein
Nature BiotechnologyLipid nanoparticle (LNP) delivery of clustered regularly interspaced short palindromic repeat (CRISPR) ribonucleoproteins (RNPs) could enable high-efficiency, low-toxicity and scalable in vivo genome editing if efficacious RNP–LNP complexes can be ...
Kai Chen +9 more
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Advanced Healthcare Materials
Poly(ethylene glycol) (PEG)–lipids are used in Food‐and‐Drug‐Administration‐approved lipid nanoparticle (LNP)–RNA drugs, which are safe and effective.
A. Sanchez +9 more
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Poly(ethylene glycol) (PEG)–lipids are used in Food‐and‐Drug‐Administration‐approved lipid nanoparticle (LNP)–RNA drugs, which are safe and effective.
A. Sanchez +9 more
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2021
The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid.
Bevers, Sanne +3 more
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The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol% of a C18-PEG2000 lipid.
Bevers, Sanne +3 more
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Advances in lipid nanoparticle mRNA therapeutics beyond COVID-19 vaccines.
NanoscaleThe remarkable success of two lipid nanoparticle-mRNA vaccines against coronavirus disease (COVID-19) has placed the therapeutic and prophylactic potential of messenger RNA (mRNA) in the spotlight. It has also drawn attention to the indispensable role of
Yeung Wu, Sinuo Yu, Irene de Lázaro
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Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines.
Trends in Molecular Medicine, 2021Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines Kelsey L. Swingle , Alex G. Hamilton , and Michael J. Mitchell 1,2,3,4,5,* Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA Abramson Cancer Center ...
K. Swingle +2 more
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2023
The present invention relates to the field of lipid nanoparticles (LPN); more specifically comprising an ionisable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in having a minimal average diameter of about 140 nm, thereby inducing a more potent immune response.
De Koker, Stefaan +2 more
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The present invention relates to the field of lipid nanoparticles (LPN); more specifically comprising an ionisable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in having a minimal average diameter of about 140 nm, thereby inducing a more potent immune response.
De Koker, Stefaan +2 more
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Stability of Lipid Excipients in Solid Lipid Nanoparticles
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Controlled Nucleation of Lipid Nanoparticles
Pharmaceutical Research, 2012We describe a nucleation-based method which allows for the generation of monodisperse lipid nanoparticles over a range of diameters. Using a set of novel zwitterionic lipids and inverse phosphocholine lipids with pKas ranging from 2 to 5, we showed how the hydrodynamic diameter of lipid nanoparticles can be systematically manipulated over a 60 nm to ...
Juliane, Nguyen +4 more
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