Results 221 to 230 of about 369,467 (261)

Pathological aspects of lipid peroxidation

Free Radical Research, 2010
Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review.
Nègre-Salvayre, Anne, Augé, Nathalie, Ayala, Victòria, Basaga, Huveyda, Boada, Jordi, Brenke, Rainer, Chapple, Sarah, Cohen, Guy, Feher, Janos, Grune, Tilman, Lengyel, Gabriella, Mann, Giovanni, Pamplona, Reinald, Poli, Giuseppe, Portero-Otín, Manuel, Riahi, Yael, Salvayre, Robert, Sasson, Shlomo, Serrano, José, Shamni, Ofer, Siems, Werner, Siow, Richard, Wiswedel, Ingrid, Zarkovic, Kamelija, Zarkovic, Neven   +24 more
openaire   +7 more sources

Lipid peroxidation in the pathogenesis of neuroborreliosis

Free Radical Biology and Medicine, 2016
This study analyzed the onset of lipid peroxidation (LPO) in neuroborreliosis and the effects of ceftriaxone therapy on LPO. Twenty-two patients with early neuroborreliosis and 22 healthy subjects were studied. LPO in the cerebrospinal fluid (CSF), as well as the plasma and urine was estimated by the levels of reactive aldehydes: 4-hydroxynonenal (4 ...
Wojciech Łuczaj, Anna Moniuszko-Malinowska, Sławomir Pancewicz, Elżbieta Skrzydlewska, Neven Zarkovic, Iwona Jarocka-Karpowicz, Luka Andrisic, Joanna Zajkowska   +7 more
openaire   +5 more sources

Lipid Peroxidation in Diabetes Mellitus

Antioxidants & Redox Signaling, 2005
There is considerable evidence that hyperglycemia represents the main cause of complications of diabetes mellitus (DM), and oxidative stress resulting from increased generation of reactive oxygen species plays a crucial role in their pathogenesis. In fact, in the absence of an appropriate response from endogenous antioxidant mechanisms, the redox ...
DAVI', Giovanni, FALCO A, PATRONO C.
openaire   +3 more sources

Rabbit liver microsomal lipid peroxidation The effect of lipid on the rate of peroxidation

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
Rat and rabbit liver microsomes catalyze an NADPH-cytochrome P-450 reductase-dependent peroxidation of endogenous lipid in the presence of the chelate, ADP-Fe3+. Although liver microsomes from both species contain comparable levels of NADPH-cytochrome P-450 reductase and cytochrome P-450, the rate of lipid peroxidation (assayed by malondialdehyde and ...
Ming Tien, Steven D. Aust
openaire   +3 more sources

[30] Microsomal lipid peroxidation

1978
Publisher Summary This chapter discusses microsomal lipid peroxidation. Lipid peroxidation is a complex process known to occur in both plants and animals. It involves the formation and propagation of lipid radicals, the uptake of oxygen, a rearrangement of the double bonds in unsaturated lipids, and the eventual destruction of membrane lipids ...
Steven D. Aust, John A. Buege
openaire   +3 more sources

Hydrogen peroxide and hematin in microsomal lipid peroxidation

Journal of Inorganic Biochemistry, 1981
Lipids of rat liver microsomes underwent peroxidation with production of malondialdehyde in the presence of H2O2 and hematin. Rates of peroxidation of 27-33 nmol of MDA formed/mg of microsomal protein/30 min were measured with 5 mM H2O2 and 10 microM hematin at 22 degrees C. Histidine (0.01 M) caused a 55% inhibition.
URSINI, FULVIO, MAIORINO, MATILDE, Ferri L, Valente M, Gregolin C.   +4 more
openaire   +4 more sources

Lipid peroxidation in tumour cells

Free Radical Biology and Medicine, 1988
Several studies point to the existence of a disturbance in the metabolism of the reactive species of oxygen in cancer cells. Based on this evidence, and in particular on a characteristic behaviour of tumour membrane lipids, namely their growth-related resistance to oxy-radical-induced peroxidation, a sequence of events is outlined that could ...
L. Masotti, T. Galeotti, CASALI, Emanuela   +2 more
openaire   +3 more sources

Effects of Melanins on Lipid Peroxidation

Applied Biochemistry and Microbiology, 2001
Effects of melanins obtained from cultured Cladosporium cladosporidae fungi and Alpha grape on Fe(2+)-induced, Fe(2+)-ascorbate-induced, and NADPH-induced lipid peroxidation in rat liver, brain, and eye were studied. Melanins were shown to inhibit the accumulation of lipid peroxidation products in vitro.
Byshneva Ln, Senchuk Vv
openaire   +3 more sources

Transferrin-dependent lipid peroxidation

Advances in Free Radical Biology & Medicine, 1986
The potential for iron bound to transferrin to be released and promote the peroxidation of phospholipid liposomes was investigated using ADP as a low molecular weight chelator and superoxide generated by the xanthine/xanthine oxidase system as the reducing agent.
Morio Saito, Lee A. Morehouse, Steven D. Aust   +2 more
openaire   +3 more sources

Assays for the Measurement of Lipid Peroxidation

2012
Physical and emotional stress, metabolic alterations, carcinogenesis or inflammation are conditions that can trigger oxidative stress, which is defined as a balance shift of redox reactions towards oxidation, resulting in the increase of reactive oxygen species (ROS). ROS are continuously formed in small quantities during the normal metabolism of cell,
Branka Mihaljević, Suzana Borović Šunjić, Morana Jaganjac, Neven Zarkovic, Ana Čipak Gašparović   +4 more
openaire   +3 more sources