Results 311 to 320 of about 1,129,041 (391)

Partial Deletion of the Carboxyl‐Terminal Signal Sequence of the Cellular Prion Protein Alters Protein Expression via Endoplasmic Reticulum–Associated Degradation

The FASEB Journal, Volume 39, Issue 17, 15 September 2025.
Knock‐in mice expressing PrP with a partial deletion of the C‐terminal signal sequence (KIBVPrP248) showed reduced PrPC expression and resistance to prion infection. The underlying mechanism is that the mutant PrP is aberrantly retained in the endoplasmic reticulum and eventually undergoes proteasomal degradation.
Miryeong Yoo, Sungeun Lee, Jieun Kim, Sunyeong Cha, Min Young Lee, Yeon Jeong Hwang, Woo‐Ri Ko, Taeeun Kim, A‐ran Kim, Trang H. T. Trinh, Young‐Mi Kim, Yong‐Pil Cheon, Chongsuk Ryou   +12 more
wiley   +1 more source

Lipid Rafts and Their Role in Signal Transduction-Mast Cells as a Model

, 2001
Petr Dráber, Lubica Dráberová, Martina Kovářová, Ivana Hálová, Pavel Tolar, Helena Cerná, Michael Boubelı́k   +6 more
openalex   +2 more sources

Application of the Mass Spectrometry–High‐Throughput Technique Over the Immunohistochemical Analysis for Human Brain Tumor Diagnosis and Prognosis: Insights Into Biomarkers' Identification for the Case Study of Grade IV Astrocytomas and Meningiomas

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Human brain tumors were commonly monitored in hospital/clinical laboratories by immunohistochemistry (IHC) technique, which provides major insights into their classification. However, this technique remains laborious and still shows pitfalls. Therefore, the current study was endeavored to reveal the assets of the application of high‐throughput
Kaouthar Louati, Fatma Kolsi, Manel Mellouli, Hanen Louati, Rim Kallel, Rania Zribi, Mahdi Borni, Leila Sellami Hakim, Amina Maalej, Sirine Choura, Mohamed Chamkha, Sami Sayadi, Zouheir Khemakhem, Tahya Sellami Boudawara, Mohamed Zaher Boudawara, Kaouthar Zribi, Fathi Safta   +16 more
wiley   +1 more source

Functional Roles of Glycoconjugates in Signal Transduction via Lipid Rafts

, 2001
Kohji Kasahara, Yutaka Sanai
openalex   +2 more sources

Transcriptional profiling after lipid raft disruption in keratinocytes identifies critical mediators of atopic dermatitis pathways.

Journal of Investigative Dermatology, 2011
Conny Mathay, Michael Pierre, M. Pittelkow, E. Depiereux, A. Nikkels, A. Colige, Y. Poumay   +6 more
semanticscholar   +1 more source

Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease

Brain and Behavior, Volume 15, Issue 9, September 2025.
This Mendelian randomization study systematically screened 338 cerebrospinal fluid metabolites and identified several with potential causal effects on Parkinson's disease, offering new insights into disease pathogenesis. ABSTRACT Background Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by motor impairments and ...
Houwen Zhang, Chunrong Li, Jialin Yu, Yu Liang, You Wu, Fangzheng Cao   +5 more
wiley   +1 more source

Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer. [PDF]

Cell Mol Life Sci
Gong H, Chen S, Liu S, Hu Q, Li Y, Li Y, Li G, Huang K, Li R, Fang L.   +9 more
europepmc   +1 more source

Lipid raft redox signaling: molecular mechanisms in health and disease.

Antioxidants and Redox Signaling, 2011
Si Jin, Fan Zhou, Foad Katirai, Pin-Lan Li   +3 more
semanticscholar   +1 more source

ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk

Brain and Behavior, Volume 15, Issue 9, September 2025.
Mendelian randomization identifies palmitoylation genes driving generalized anxiety disorder (GAD) risk, notably ZDHHC5 and ZDHHC13. ZDHHC5 promotes GAD pathogenesis by modulating SSC‐A on CD4+ T cells, revealing novel immune‐mediated mechanisms and therapeutic targets for GAD.
Fuqiang Sun, Gengchen Lu, Nannan Li, Kun Dai, Zhe Ren, Ruimin Ma, Yifei Feng, Shuo Zong, Bin Cheng   +8 more
wiley   +1 more source

Destination lipid rafts [PDF]

Nature Reviews Molecular Cell Biology, 2002
openaire   +1 more source