Results 331 to 340 of about 1,129,041 (391)
Exosomes in Metabolic Diseases: From Molecular Mechanisms to Clinical Applications
MedComm – Future Medicine, Volume 4, Issue 3, September 2025.We summarize recent progress in exosome biology and elucidate their roles in interorgan communication networks underlying metabolic pathogenesis. We also comprehensively examine the evolving application of exosomes in metabolic disease management, with a focus on critically evaluating preclinical and clinical advances in exosome‐mediated therapeutic ...
Yanting Wu +3 more
wiley +1 more source
Analysis of Population Structure and Selection Signatures in Two Iraqi Fat‐Tailed Sheep Breeds
Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.Awassi sheep exhibit clear genetic separation, whereas Hamdani sheep show an admixed profile, with iHS, ROH and Tajima's D analyses identifying breed‐specific candidate genes. Enrichment in immune response, hormone regulation and cellular signalling pathways highlights adaptive evolution and guides future breeding and conservation.
Mervan Bayraktar +6 more
wiley +1 more source
Microbial Biotechnology, Volume 18, Issue 9, September 2025.Investigation of outer membrane vesicles from Acinetobacter baumannii for potential biotechnological applications. ABSTRACT Outer membrane vesicles (OMVs) are extracellular nanostructures released from Gram‐negative bacteria. Acinetobacter baumannii OMVs (AbOMVs) have been extensively studied and can thus be used as a model for understanding multiple ...
Beatriz Cano‐Castaño +5 more
wiley +1 more source
A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains
The FEBS Journal, Volume 292, Issue 17, Page 4477-4486, September 2025.Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley +1 more source
Journal of Neurochemistry, Volume 169, Issue 9, September 2025.We identified a previously unrecognized mechanism by which the extracellular protein Reelin increases sphingomyelin synthesis in hippocampal neurons, increasing plasma membrane sphingomyelin, and GPI‐anchored proteins. This coupling of extracellular signaling to membrane lipid remodeling provides new insight into how Reelin shapes neuronal surface ...
Yuto Takekoshi +7 more
wiley +1 more source
Obesity Reviews, Volume 26, Issue 9, September 2025.ABSTRACT Objectives Gestational diabetes mellitus (GDM), affecting one in seven pregnant women worldwide, can have short‐ and long‐term adverse outcomes for both the mother and her baby. Despite a raft of prognostic models aiming to predict adverse GDM outcomes, very few have impacted clinical practice.
Yasmina Al Ghadban +8 more
wiley +1 more source
Reproduction in Domestic Animals, Volume 60, Issue S3, September 2025.ABSTRACT Extracellular Vesicles (EVs) are small, membrane‐bound particles released by cells into biological fluids, where they function as mediators of intercellular communication. These vesicles transport a diverse array of bioactive molecules, including proteins, lipids, and nucleic acids, and play essential roles in regulating physiological and ...
Alireza Fazeli +3 more
wiley +1 more source
Nicht‐Amphiphile Antimikrobielle Polymere
Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.Gänzlich nicht‐amphiphile antimikrobielle Polymere (APs), die deutliche Bioaktivität und ausgezeichnete Selektivitäten zeigen, werden vorgestellt. Die Bedeutung von Wasserstoffbrücken‐Bindungen wird durch die Segregation von APs an bakteriellen Membranmodellen und Bakterien hervorgehoben. Dieses Verhalten wurde für amphiphile Polymere nicht beobachtet.
Alain M. Bapolisi +15 more
wiley +1 more source
Non‐Amphiphilic Antimicrobial Polymers
Angewandte Chemie International Edition, Volume 64, Issue 33, August 11, 2025.Completely non‐amphiphilic antimicrobial polymers (APs) that possess significant bioactivity and excellent selectivity are presented. The importance of hydrogen‐bonding interactions is highlighted by segregation of APs on bacterial membrane models and bacteria, a behavior absent in amphiphilic polymers.
Alain M. Bapolisi +15 more
wiley +1 more source