Results 91 to 100 of about 75,080 (297)

Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation

Frontiers in Immunology, 2019
The receptor for advanced glycation end products (RAGE) interacts with various molecules in the cell membrane to induce an inflammatory response. The cytolethal distending toxin (CDT) produced by Campylobacter jejuni contains three subunits: CdtA, CdtB ...
Hwai-Jeng Lin, Hwai-Jeng Lin, Zhi-Pei Jiang, Zhi-Pei Jiang, Horng-Ren Lo, Chun-Lung Feng, Chun-Lung Feng, Chih-Jung Chen, Chia-Yu Yang, Chia-Yu Yang, Mei-Zi Huang, Hui-Yu Wu, Yu-An Chen, Yu Chen, Cheng-Hsun Chiu, Cheng-Hsun Chiu, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai, Chih-Ho Lai   +19 more
doaj   +1 more source

Anesthetics interacting with lipid rafts

European Journal of Pharmaceutical Sciences, 2013
The exact mechanism by which anesthetics induce cell membrane-mediated modifications is still an open question. Although the fluidization effect of the anesthetic molecules on the cellular membrane is widely recognized, it is not known if anesthetics show any preference for specific membrane domains, namely the lipid rafts.
Cátia, Bandeiras, Ana Paula, Serro, Konstantin, Luzyanin, Anabela, Fernandes, Benilde, Saramago   +4 more
openaire   +2 more sources

Cholesterol, lipid rafts, and disease [PDF]

Journal of Clinical Investigation, 2002
Lipid rafts are dynamic assemblies of proteins and lipids that float freely within the liquid-disordered bilayer of cellular membranes but can also cluster to form larger, ordered platforms. Rafts are receiving increasing attention as devices that regulate membrane function in eukaryotic cells.
Simons, K., Ehehalt, R.
openaire   +3 more sources

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

Angewandte Chemie, EarlyView.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire, Wesley J. Olivier, Debabrata Maiti, Alex C. Bissember   +3 more
wiley   +2 more sources

GM1 improves neurofascin155 association with lipid rafts and prevents rat brain myelin injury after hypoxia-ischemia

Brazilian Journal of Medical and Biological Research, 2011
White matter injury characterized by damage to myelin is an important process in hypoxic-ischemic brain damage (HIBD). Because the oligodendrocyte-specific isoform of neurofascin, neurofascin 155 (NF155), and its association with lipid rafts are ...
Y.P. Zhang, Q.L. Huang, C.M. Zhao, J.L. Tang, Y.L. Wang   +4 more
doaj   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Rafts defined: a report on the Keystone symposium on lipid rafts and cell function

Journal of Lipid Research, 2006
The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23–28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts.
Linda J. Pike
doaj   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source