Results 41 to 50 of about 593,917 (313)

Role of CYP27A in cholesterol and bile acid metabolism

Journal of Lipid Research, 2005
The CYP27A gene encodes a mitochondrial cytochrome P450 enzyme, sterol 27-hydroxylase, that is expressed in many different tissues and plays an important role in cholesterol and bile acid metabolism. In humans, CYP27A deficiency leads to cerebrotendinous
Sandrine Dubrac, Steven R. Lear, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Jaya Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Patricia J. Blanche, Ronald M. Krauss, Ashok K. Batta, Gerald Salen, Frederick J. Suchy, Nobuyo Maeda, Sandra K. Erickson   +14 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Discovery of a lipid synthesising organ in the auditory system of an insect

, 2012
Weta possess typical Ensifera ears. Each ear comprises three functional parts: two equally sized tympanal membranes, an underlying system of modified tracheal chambers, and the auditory sensory organ, the crista acustica.
Lomas Kathryn F., Greenwood David R., Greenwood, David, Parsons, Stuart, Greenwood, David R., Joseph C. Jackson, James F C Windmill, Joseph C Jackson, Kathryn F Lomas, Windmill, James F.C., Corfield, Jeremy, Kathryn F. Lomas, Lomas, Kathryn F., Jeremy Corfield, Stuart Parsons, Jackson, Joseph C., Jackson Joseph C., Corfield Jeremy, David R. Greenwood, Jackson, Joseph, Windmill, James, Lomas, Kathryn, David R Greenwood, Windmill James FC., James F. C. Windmill, Parsons Stuart   +25 more
core   +1 more source

A Linear Programming Approach for Modeling and Simulation of Growth and Lipid Accumulation of Phaeodactylum tricornutum

Energies, 2013
The unicellular microalga Phaeodactylum tricornutum exhibits the ability to accumulate triacylglycerols to a high specific content when nutrients are limited in the culture medium. Therefore, the organism is a promising candidate for biodiesel production.
Clemens Posten, Robert Dillschneider
doaj   +1 more source

mTOR Plays a Conserved Role in Regulation of Nutritional Metabolism in Bivalve Sinonovacula constricta

Journal of Marine Science and Engineering, 2023
The mammalian target of rapamycin (mTOR) has been shown to play a central role in regulating cell growth and metabolism. However, little is known about the function of mTOR in nutrient metabolism in bivalve mollusks.
Qian Zhang, Yanrong Li, Kai Liao, Deshui Chen, Yangyang Qiu, Xiaojun Yan, Jilin Xu   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Mutations That Alter the Bacterial Cell Envelope Increase Lipid Production

mBio, 2017
Lipids from microbes offer a promising source of renewable alternatives to petroleum-derived compounds. In particular, oleaginous microbes are of interest because they accumulate a large fraction of their biomass as lipids.
Kimberly C. Lemmer, Weiping Zhang, Samantha J. Langer, Alice C. Dohnalkova, Dehong Hu, Rachelle A. Lemke, Jeff S. Piotrowski, Galya Orr, Daniel R. Noguera, Timothy J. Donohue   +9 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

Journal of Lipid Research, 2006
Cell dysfunction and death induced by lipid accumulation in nonadipose tissues, or lipotoxicity, may contribute to the pathogenesis of obesity and type 2 diabetes. However, the mechanisms leading to lipotoxic cell death are poorly understood. We recently
Nica M. Borradaile, Xianlin Han, Jeffrey D. Harp, Sarah E. Gale, Daniel S. Ory, Jean E. Schaffer   +5 more
doaj   +1 more source