Results 21 to 30 of about 22,082 (266)
Mouse lipidomics reveals inherent flexibility of a mammalian lipidome [PDF]
Scientific Reports, 2021 AbstractLipidomics has become an indispensable method for the quantitative assessment of lipid metabolism in basic, clinical, and pharmaceutical research. It allows for the generation of information-dense datasets in a large variety of experimental setups and model organisms.
Michał A. Surma +5 more
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Lipidomics unveils the complexity of the lipidome in metabolic diseases [PDF]
Clinical and Translational Medicine, 2018 AbstractDysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions.
Todd A. Lydic, Young‐Hwa Goo
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Clinica Chimica Acta, 2020 The present article examines recently published literature on lipids, mainly focusing on research involving glycero-, glycerophospho- and sphingo-lipids. The primary aim is identification of distinct profiles in biologic lipidomic systems by ultra-high-performance liquid chromatography (UHPLC) coupled with mass spectrometry (MS, tandem MS) with ...
Henri F. Avela, Heli Sirén
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LC-MS and High-Throughput Data Processing Solutions for Lipid Metabolic Tracing Using Bioorthogonal Click Chemistry. [PDF]
Angew Chem Int Ed EnglThis study introduces an integrated analytical and bioinformatics platform for high‐throughput tracing of lipid metabolism using bioorthogonal alkyne fatty acids and optimized LC‐MS workflow. Applied to human fibrosarcoma cells, the method traced fatty acid metabolism, revealing nuances in sphingolipid routing and metabolic bottlenecks, highlighting ...
Nepachalovich P +7 more
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Diagnosis of Ia–Ic stages of serous high-grade ovarian cancerby the lipid profile of blood serum
Гинекология, 2021 Background. Ovarian cancer is the first fatal malignancy of the female reproductive system. Early detection is associated with better outcomes, but is significantly difficult because of asymptomatic or low-symptomatic course. Aim.
Mariia V. Iurova +7 more
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Nature Communications, 2023 The circulatory lipidome is a valuable source for disease markers, but reliable marker discovery requires continuous development of lipidomic methods for large-scale clinical profiling.
Raissa Lerner +7 more
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The Lipidome Fingerprint of Longevity [PDF]
Molecules, 2020 Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell
Mariona Jové +7 more
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Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules
Frontiers in Cell and Developmental Biology, 2021 Lipid metabolism plays a basic role in renal physiology, especially in tubules. Hypoxia and hypoxia-induced factor (HIF) activation are common in renal diseases; however, the relationship between HIF and tubular lipid metabolism is poorly understood ...
Wenju Li +5 more
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Recent advances in expanding the coverage of the lipidome [PDF]
, 2017 The lipidome comprises a large array of molecules with diverse physicochemical properties. Lipids are structural components of cells, act as a source of energy, and function as signaling mediators.
Kamphorst, Jurre J., Tumanov, Sergey
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Frontiers in Immunology, 2022 BackgroundSystemic immune inflammation is a key mediator in the progression of coronary artery disease (CAD), concerning various metabolic and lipid changes. In this study, the relationship between the inflammatory index and metabolic profile in patients
Qian Zhu +13 more
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