Results 161 to 170 of about 34,809 (298)

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

Evaluating Lipidomic Circuit Modulation in Glaucoma Management [PDF]

Glaucoma, a sight-threatening condition, is primarily characterized by elevated intraocular pressure (IOP). Despite its importance, the relationship between IOP and glaucoma progression is complex. Livne-Bar et al.
Mathew, David Jose
core  

Lipidomic analysis on larvae after treatment with 20E

Lipidomic profiling further revealed a substantial remodeling of lipid species, with reduced TG and PE, alongside increased free fatty acids (FFA) and select phospholipids, highlighting the profound impact of 20E on lipid ...
Yu, Jing
core   +1 more source

Agricultural and environmental drivers of variation in the composition of food crops: A scoping review

PLANTS, PEOPLE, PLANET, EarlyView.
Agricultural management and environmental conditions influence the biochemical composition of food crops; however, the specific drivers of this variation remain insufficiently understood, despite their importance for climate change adaptation and human health.
Kat Morgan, Teresa Warne, Sahar Toulabi, Fangzhou Li, Amanda Birnbaum, Shawn Ehlers Cheang, Cheng‐Yu Weng, Warangkana Srichamnong, Simab Kanwal, Linda Nana Esi Aduku, Charles Apprey, Kifle Habte Balcha, Herman Erick Lutterodt, Madeleine McGuinness, Bo Wallace, Layla Manoochehri, Alex C. McAlvay, Mary Ann Nunoo, Pearl Boamah Agyekum, Reginald A. Annan, Charlene van Buiten, Mariana Barboza, John de la Parra, Selena Ahmed, Sarah Brinkley   +24 more
wiley   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study. [PDF]

EClinicalMedicine
Dakic A, Wu J, Wang T, Meikle TG, Huynh K, Yi C, Beyene HB, Salim A, Cinel M, Mellett N, Duong T, Faulkner AN, van Buuren-Milne M, Bhagwat A, Shaw JE, Magliano DJ, Watts GF, Hung J, Hui J, Beilby JP, Blangero J, Moses EK, Southey MC, Milne RL, Hodge AM, McNeil JJ, Lacaze P, Yu C, Wolfe R, Yang JY, Grieve SM, Chow CK, Vernon ST, Gray MP, Figtree GA, Morton JI, Scuffham P, Woodward M, Kalman L, Paige E, Carrington MJ, Inouye M, Giles C, Meikle PJ.   +43 more
europepmc   +1 more source

Common lipidomic signatures across distinct acute brain injuries in patient outcome prediction

Lipidomic alterations have been associated with various neurological diseases. Examining temporal changes in serum lipidomic profiles, irrespective of injury type, reveals promising prognostic indicators.
Riikka Takala, Jussi P. Posti, Jukka Puolitaival, Eero Castrén, Jaakko Rinne, Carolyn Bennett, Johannes Falter, Tomi Rantamäki, Aditya Jhaveri, Susanna Roine, Fredrika Koskimäki, Anni I. Nieminen, Janek Frantzén, Abhinav Srinath, Sulo Kolehmainen, Romuald Girard, Santtu Hellström, Seán B. Lyne, Miro Jänkälä, Antti Sajanti, Ying Cao, Melissa Rahi, Kenneth Nazir, Janne Koskimäki   +23 more
core   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Lipidomic predictors of residual insulin production in adults with newly diagnosed type 1 diabetes

IntroductionAlterations in the lipidomic profile have been implicated in the development and disease progression in type 1 diabetes. We have previously demonstrated that the lipidomic profile at the time of diagnosis could predict residual insulin ...
Sulek, Karolina, Hostrup, Pernille Emilie, Pociot, Flemming   +2 more
core   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source